Unité de Recherche Animal et Fonctionnalités des Produits Animaux (UR AFPA), Nancy University, INRA, 2 av de la forêt de Haye, Vandoeuvre-lès-Nancy Cedex, France.
Environ Sci Technol. 2010 Apr 1;44(7):2682-8. doi: 10.1021/es9036786.
This study investigated milk excretion kinetics of PCBs, tetra-BDE (BDE 47), and penta-BDE (BDE 99) in goats exposed to contaminated soil under controlled conditions. The animals were fed (80 days) with feed containing 5% of contaminated soil. During this exposure period, milk was analyzed weekly. At the end of the experiment the PCBs and PBDEs retained in hepatic and adipose tissues were also determined. The soil-milk carry over rates (CORs) of PCBs ranged from 6 to 62%. This result suggests that a large part of ingested soil-bound PCBs was recovered in milk. Significantly different levels between the congeners were reported in the tissues (fat, liver). BDE 47 and 99 excretions in milk achieved a plateau after 2 weeks of exposure, and their corresponding CORs were about 30%. These two congeners showed a significantly (P < 0.05) lower accumulation in the adipose tissue than the major PCB congeners. The concentrations of BDE 47 and 99 in the liver were the same as PCB concentrations. This result suggests that the low brominated congeners are submitted to the metabolism more extensively than the major PCBs.
本研究在受控条件下调查了暴露于污染土壤的山羊中多氯联苯（PCBs）、四溴二苯醚（BDE-47）和五溴二苯醚（BDE-99）的牛奶排泄动力学。这些动物用含有 5%污染土壤的饲料喂养（80 天）。在暴露期间，每周分析牛奶。实验结束时，还测定了肝脏和脂肪组织中残留的多氯联苯和 PBDEs。PCBs 的土壤-牛奶转移率（CORs）范围为 6%至 62%。这一结果表明，摄入的大部分土壤结合多氯联苯都在牛奶中得到了回收。组织（脂肪、肝脏）中报道的同系物之间存在显著差异。BDE-47 和 99 在暴露 2 周后在牛奶中的排泄达到了稳定期，其相应的 COR 约为 30%。这两种同系物在脂肪组织中的积累明显（P<0.05）低于主要 PCB 同系物。BDE-47 和 99 在肝脏中的浓度与 PCB 浓度相同。这一结果表明，低溴代同系物比主要 PCB 更广泛地进行代谢。
