Institute of Health & Biomedical Innovation, School of Life Sciences, Faculty of Science, Queensland University of Technology, Brisbane, Qld, Australia.
Am J Reprod Immunol. 2010 Jun;63(6):576-86. doi: 10.1111/j.1600-0897.2010.00819.x. Epub 2010 Feb 28.
The number of genital tract Chlamydia trachomatis infections is steadily increasing worldwide, with approximately 50-70% of infections asymptomatic. There is currently no uniform screening practice, current antibiotic treatment has failed to prevent the increased incidence, and there is no vaccine available. We examined studies on the epidemiology of C. trachomatis infections, the effects infections have on the female reproductive tract and subsequent reproductive health and what measures are being taken to reduce these problems. Undetected or multiple infections in women can lead to the development of severe reproductive sequelae, including pelvic inflammatory disease and tubal infertility. There are two possible paradigms of chlamydial pathogenesis, the cellular and immunological paradigms. While many vaccine candidates are being extensively tested in animal models, they are still years from clinical trials. With no vaccine available and antibiotic treatment unable to halt the increased incidence, infection rates will continue to increase and cause a significant burden on health care systems.
全球生殖道沙眼衣原体感染的数量在稳步增加，约有 50-70%的感染无症状。目前没有统一的筛查方法，目前的抗生素治疗未能预防发病率的增加，也没有可用的疫苗。我们研究了沙眼衣原体感染的流行病学、感染对女性生殖道及随后的生殖健康的影响，以及正在采取哪些措施来减少这些问题。女性未被发现或多次感染可能导致严重的生殖后遗症，包括盆腔炎和输卵管不孕。衣原体发病机制有两种可能的模式，即细胞和免疫模式。虽然许多疫苗候选物正在动物模型中进行广泛测试，但它们距离临床试验还有数年时间。由于没有疫苗可用，抗生素治疗也无法阻止发病率的增加，感染率将继续上升，给医疗保健系统带来巨大负担。
