丙戊酸与乙琥胺对戊四氮诱导的大鼠癫痫现象的协同抗惊厥作用。

Synergistic anticonvulsant effect of valproic acid and ethosuximide on pentylenetetrazole-induced epileptic phenomena in rats.

作者信息

Musolino R, Gallitto G, De Domenico P, Bonazinga M M, Sturniolo R, Labate C, Di Perri R

机构信息

Neurological Clinic, University of Messina, Italy.

出版信息

J Int Med Res. 1991 Jan-Feb;19(1):55-62. doi: 10.1177/030006059101900108.

DOI:10.1177/030006059101900108

PMID:2019316

Abstract

The possible synergistic effect of valproic acid and ethosuximide in combination on pentylenetetrazole-induced epilepsy was investigated in rats. Valproic acid and ethosuximide administered intraperitoneally both showed dose-dependent anti-epileptic activity towards pentylenetetrazole-induced myoclonias and tonic-clonic seizures. The valproic acid-ethosuximide combination had a synergistic pharmacological effect. Against myoclonias combined valproic acid-ethosuximide produced a non-significant decrease in the effective dose of both drugs compared with treatment with either drug alone. In the case of tonic-clonic seizures the protective effect against the seizures was significantly increased by combined treatment compared with treatment with either drug alone. Neither plasma concentrations nor any other pharmacokinetic parameters were significantly changed when the same doses of valproic acid and ethosuximide were given, singly or in combination.

摘要

在大鼠中研究了丙戊酸和乙琥胺联合使用对戊四氮诱导的癫痫可能产生的协同作用。腹腔注射丙戊酸和乙琥胺对戊四氮诱导的肌阵挛和强直阵挛性发作均表现出剂量依赖性抗癫痫活性。丙戊酸 - 乙琥胺组合具有协同药理作用。对于肌阵挛，与单独使用任一药物治疗相比，丙戊酸 - 乙琥胺联合使用使两种药物的有效剂量有非显著性降低。对于强直阵挛性发作，与单独使用任一药物治疗相比，联合治疗对发作的保护作用显著增强。当给予相同剂量的丙戊酸和乙琥胺单独或联合使用时，血浆浓度和任何其他药代动力学参数均未发生显著变化。