丙戊酸盐与乙琥胺在成年和未成年大鼠中抗癫痫作用的比较。
Comparison of antiepileptic action of valproate and ethosuximide in adult and immature rats.
作者信息
Mares P, Velisék L
机构信息
Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
出版信息
Pol J Pharmacol Pharm. 1987 Sep-Oct;39(5):505-12.
The antiepileptic action of ethosuximide and valproate was studied in immature rats in the pentetrazole (PTZ) model. Valproate antagonized the effect of PTZ in rats of all ages, while ethosuximide was effective only in rats of 25 or more days of age: in 18 day old rats it modified the PTZ seizure pattern and was ineffective in younger animals or only slightly affected the PTZ seizure pattern. Similarly, the ECoG studies have shown that valproate antagonizes PTZ action at all ages, while ethosuximide only in mature rats.
在戊四氮（PTZ）模型中，对未成熟大鼠研究了乙琥胺和丙戊酸盐的抗癫痫作用。丙戊酸盐可拮抗PTZ对所有年龄段大鼠的作用，而乙琥胺仅对25日龄及以上的大鼠有效：在18日龄大鼠中，它改变了PTZ的癫痫发作模式，对年幼动物无效或仅轻微影响PTZ的癫痫发作模式。同样，脑电图（ECoG）研究表明，丙戊酸盐在所有年龄段均拮抗PTZ的作用，而乙琥胺仅在成年大鼠中有效。
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