Cai Wei, Deng Jia-Yun, Ouyang Bing, Li Ping, Li Feng, Zhou Ding-You, Xu Jia-Yuan, Sha Kai-Fen, Chen Xiao-Fang
Sichuan Province Center for Disease Control and Prevention, Chengdu 610041, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2009 Aug;30(8):820-3.
To study the epidemiological characteristics of Keshan disease (KD) and its trend so as to provide evidences for further research, prevention and treatment of the disease in Sichuan province.
Based on KD related data from 1990 to 2008, descriptive method was used to analyze the epidemiological characteristics of KD.
87 KD cases were identified during the 19 years. All cases were children from the countryside, with majority of them were Yi nationality. Age of the patients ranged from 5 months to 18 years, with majority at 2 - 6 year-olds. The annual incidence rates were from 0/100 000 to 1.73/100 000 with 1999 the highest (1.73/100 000). A total number of 310 preclinical or chronic KD cases were identified and the total detection rates were between 0.28% and 2.8%, with 1992 the highest. As for levels of blood selenium during the 19 years: 1995 appeared the lowest (0.1345 microg/g), followed by 1990 - 2000 (0.1558 microg/g) but all of them fell in to the level in the KD epidemic areas.
There were 5 stages in the development trend of KD disease in Sichuan province, with 2 ascending and 3 descending. The differences between any of the two stages were statistically significant. The 3 descending stages all appeared right after the selenium supplement intervention was taken. Our data showed that the program of selenium supplement was closely related to the incidence of KD, suggesting that a long term mechanism of Selenium supplement in the epidemic areas should be taking into account.
研究四川省克山病（KD）的流行病学特征及其变化趋势，为进一步开展该病的防治研究提供依据。
利用1990 - 2008年克山病相关资料，采用描述性方法分析克山病的流行病学特征。
19年间共确诊87例克山病病例。所有病例均为农村儿童，以彝族为主。患者年龄5个月至18岁，以2 - 6岁居多。年发病率为0/10万至1.73/10万，1999年最高（1.73/10万）。共检出潜在型和慢性克山病病例310例，总检出率为0.28% - 2.8%，1992年最高。19年间血硒水平：1995年最低（0.1345μg/g），其次是1990 - 2000年（0.1558μg/g），均处于克山病病区水平。
四川省克山病病情发展趋势呈5个阶段，其中上升阶段2个，下降阶段3个，各阶段间差异有统计学意义。3个下降阶段均出现在补硒干预之后。提示补硒措施与克山病发病密切相关，应考虑在病区建立长期补硒机制。
