Huang Jin, Zhang Hui-zhen, Zheng Li, Zhou Juan, Jiang Zhi-ming
Department of Pathology, Shanghai 6th People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China.
Zhonghua Bing Li Xue Za Zhi. 2009 Dec;38(12):820-3.
To study the clinicopathologic and radiologic features of dedifferentiated chondrosarcoma, focusing on its diagnosis and differential diagnosis.
Clinical, radiological and pathologic findings of 14 cases of dedifferentiated chondrosarcoma (including biopsy and surgical specimens) were analyzed by hematoxylin and eosin stained sections and immunohistochemistry.
The mean age of patients was 52 years. The male-to-female ratio was 9:5. The most common sites of involvement were pelvis, femur and humerus, similar to the conventional chondrosarcoma. Radiologically, they were malignant tumors with dimorphic pattern. Grossly, central chondrosarcomas were more common than those of the peripheral. An essential histological feature of dedifferentiated chondrosarcoma was an abrupt interface between the low-grade cartilaginous tumor and high-grade anaplastic sarcoma. The most common dedifferentiated components were osteosarcoma, malignant fibrous histocytoma and fibrosarcoma. False negative diagnosis and erroneous diagnosis were frequent when only one-time biopsy was available.
Dedifferentiated chondrosarcoma is a rare subtype of chondrosarcoma with poor prognosis, which has different features of clinical manifestation, imaging features and pathological characteristics, compared to conventional chondrosarcoma and chondroblastic osteosarcoma.
研究去分化软骨肉瘤的临床病理及影像学特征，重点关注其诊断与鉴别诊断。
对14例去分化软骨肉瘤（包括活检及手术标本）的临床、放射学及病理结果进行分析，采用苏木精-伊红染色切片及免疫组织化学方法。
患者平均年龄52岁。男女比例为9:5。最常受累部位为骨盆、股骨和肱骨，与传统软骨肉瘤相似。放射学上，它们是具有双相模式的恶性肿瘤。大体上，中央型软骨肉瘤比周围型更常见。去分化软骨肉瘤的一个重要组织学特征是低级别软骨肿瘤与高级别间变性肉瘤之间存在突然的界面。最常见的去分化成分是骨肉瘤、恶性纤维组织细胞瘤和纤维肉瘤。仅进行一次活检时，假阴性诊断和错误诊断很常见。
去分化软骨肉瘤是软骨肉瘤的一种罕见亚型，预后较差，与传统软骨肉瘤和成软骨细胞性骨肉瘤相比，具有不同的临床表现、影像学特征和病理特征。
