Huang Jin, Jiang Zhiming, Yang Qingcheng, Zhang Huizhen
Shanghai Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, China.
Int J Surg Pathol. 2013 Feb;21(1):48-53. doi: 10.1177/1066896912451322. Epub 2012 Jun 25.
Dedifferentiated chondrosarcomas (DDCS) account for approximately 10% of all chondrosarcoma cases and its 5-year survival is only 10%. The dedifferentiated components of DDCS could be osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. In this article, the authors report a rare case of DDCS in a 19-year-old female, in which the dedifferentiated component showed a close histological resemblance to a giant cell tumor of bone. Radiological diagnosis revealed an expansive osteolytic lesion in the epiphysis of right proximal humerus, which also extended to the diaphysis with irregular calcification and focal cortical breakthrough. The biopsy tissue contained the features of a giant cell tumor of bone and well-differentiated cartilage. Pathological examination revealed a biphasic tumor comprising of low-grade chondrosarcoma and nonchondroid giant cell-rich lesion similar to conventional giant cell tumor of bone, and there is an abrupt transition between the 2 components.
去分化软骨肉瘤（DDCS）约占所有软骨肉瘤病例的10%，其5年生存率仅为10%。DDCS的去分化成分可以是骨肉瘤、恶性纤维组织细胞瘤和纤维肉瘤。在本文中，作者报告了一例罕见的19岁女性DDCS病例，其中去分化成分在组织学上与骨巨细胞瘤极为相似。放射学诊断显示右肱骨近端骨骺有一膨胀性溶骨性病变，该病变也延伸至骨干，伴有不规则钙化和局灶性皮质突破。活检组织具有骨巨细胞瘤和分化良好的软骨的特征。病理检查显示为双相肿瘤，由低度软骨肉瘤和类似于传统骨巨细胞瘤的富含非软骨巨细胞的病变组成，且这两种成分之间存在突然转变。
