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[去分化软骨肉瘤:影像学与病理对照]

[Dedifferentiated chondrosarcoma: radiologic-pathologic correlation].

作者信息

Bierry G, Feydy A, Larousserie F, Pluot E, Guerini H, Campagna R, Dufau-Andreu C, Anract P, Babinet A, Dietemann J L, Chevrot A, Drapé J L

机构信息

Service de Radiologie B, Hôpital Cochin, 27, faubourg Saint-Jacques, 750014 Paris.

出版信息

J Radiol. 2010 Mar;91(3 Pt 1):271-9. doi: 10.1016/s0221-0363(10)70038-x.

Abstract

Dedifferentiated chondrosarcomas are highly malignant tumors characterized by conventional low-grade chondrosarcoma with abrupt transition to foci that have dedifferentiated into a higher-grade noncartilaginous more aggressive sarcoma. The dedifferentiated component, an osteosarcoma or fibrosarcoma, determines the prognosis. Its identification is key for management. A diagnosis of dedifferentiated chondrosarcoma should be suggested by the presence of "tumoral dimorphism" with cartilaginous component and aggressive lytic component invading adjacent soft tissues.

摘要

去分化软骨肉瘤是高度恶性肿瘤,其特征为传统的低级别软骨肉瘤突然转变为已去分化为更高级别的非软骨性、侵袭性更强的肉瘤的病灶。去分化成分,即骨肉瘤或纤维肉瘤,决定预后。其识别是治疗的关键。去分化软骨肉瘤的诊断应依据存在“肿瘤二态性”,即软骨成分和侵袭相邻软组织的侵袭性溶骨性成分。

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