Ma Ya-ting, Lian Shi-yong, Liu Zhi-cai, Cheng Lan-ping, Li Bian-yun, Quan Pei-liang, Lu Jian-bang, Sun Xi-bin
College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2009 Dec;43(12):1100-4.
To analyze the survival level and variation of esophageal cancer in Linzhou city of Henan province from 1988 to 2004, and evaluate the effects of diagnosis and treatments on esophageal cancer in this area.
All incidence and death records for esophageal cancer during 1988 to 2004 were collected from Linzhou Tumor Registry. Cases with duplicate information or death certificate only were excluded. A total of 12,160 cases of esophageal cancer were collected, of which, 6914 cases were male, and 5246 cases were female. The sex-specific and age-specific probabilities of survival in 1992, 1997 and 2002 were calculated and linked to the data of incidence and death on esophageal cancer in this area. Five-year observed survival rate and five-year relative survival rate during 1990 to 1994, 1995 to 1999, 2000 to 2004 were calculated respectively using period survival analysis and cohort survival analysis and Z test.
The 5-year relative survival rates among the three-episode were 28.24%, 35.24% and 40.76% respectively during 1988 to 2004. This showed an increasing trend by periods (Z values were 3.94 and 3.07, P < 0.05). The 5-year observed survival rates in men among the three-episode were 13.67%, 18.08% and 22.46% respectively, the 5-year relative survival rates were 29.94%, 36.96% and 38.40%. The 5-year observed survival rates in women among the three-episode were 15.56%, 19.29% and 28.01% respectively, the 5-year relative survival rates were 26.78%, 33.12% and 43.70%. During the two former periods, there was no significant difference in the 5-year observed survival rate and relative survival rate between men and women (Z values of observed survival rate were 1.48 and 0.88, P > 0.05. Z values of relative survival rate were 1.27 and 1.50, P > 0.05). In the third period, the 5-year observed survival rate and relative survival rate in women was higher than that in men (observed survival rate Z = 3.56, P < 0.05; relative survival rate Z = 2.09, P < 0.05). The relative survival rate that calculated using period method (respectively 35.24% and 40.76%) was higher than that using cohort method (respectively 28.77% and 33.35%) from 1995 to 1999, and from 2000 to 2004.
The survival rate on esophageal cancer in Linzhou city was increasing in the three different periods. This indicated a rising status in the secondary prevention and clinical diagnosis and treatments on esophageal cancer.
分析河南省林州市1988年至2004年食管癌的生存水平及变化情况，并评估该地区食管癌诊断和治疗的效果。
从林州肿瘤登记处收集1988年至2004年期间所有食管癌的发病和死亡记录。排除信息重复或仅有死亡证明的病例。共收集到12160例食管癌病例，其中男性6914例，女性5246例。计算1992年、1997年和2002年按性别和年龄分层的生存概率，并与该地区食管癌的发病和死亡数据相联系。分别采用时期生存分析、队列生存分析和Z检验计算1990年至1994年、1995年至1999年、2000年至2004年期间的五年观察生存率和五年相对生存率。
1988年至2004年三个时间段的五年相对生存率分别为28.24%、35.24%和40.76%。呈逐年上升趋势（Z值分别为3.94和3.07，P<0.05）。三个时间段男性的五年观察生存率分别为13.67%、18.08%和22.46%，五年相对生存率分别为29.94%、36.96%和38.40%。女性的五年观察生存率分别为15.56%、19.29%和28.01%，五年相对生存率分别为26.78%、33.12%和43.70%。在前两个时间段，男性和女性的五年观察生存率和相对生存率差异无统计学意义（观察生存率Z值分别为1.48和0.88，P>0.05。相对生存率Z值分别为1.27和1.50，P>0.05）。在第三个时间段，女性的五年观察生存率和相对生存率高于男性（观察生存率Z=3.56，P<0.05；相对生存率Z=2.09，P<0.05）。1995年至1999年以及2000年至2004年，采用时期法计算的相对生存率（分别为35.24%和40.76%）高于队列法（分别为28.77%和33.35%）。
林州市食管癌生存率在三个不同时间段呈上升趋势。这表明食管癌二级预防以及临床诊断和治疗水平有所提高。
