[中国磁县1974 - 2002年食管癌发病率和死亡率研究] - Suppr

He Yu-tong, Hou Jun, Chen Zhi-feng, Song Guo-hui, Qiao Cui-yun, Meng Fan-shu, Ji Hong-xin, Chen Chao

Hebei Cancer Institute, Shijiazhuang 050011, China.

Zhonghua Liu Xing Bing Xue Za Zhi. 2006 Feb;27(2):127-31.

OBJECTIVE

To describe the incidence and mortality rates of esophageal cancer from 1974-2002 in Cixian county of Hebei province. Basic information on comparative geographical, epidemiological, and clinical research was collected.

METHODS

In early 1970s, cancer registry system in Cixian was established, collecting information on all the esophageal cancer cases in Cixian. Data was checked manually, then computerized, coded and analyzed using the software--SPSS 11.5.

RESULTS

From 1974 to 2002, there were 18 471 esophageal cancer cases in Cixian, with 11 068 males and 7403 females, respectively. The age standardized incidence rate (ASR) for males was 208.77 per 100,000, while 120.47 per 100,000 for females. The trend of incidence rate of esophageal cancer had decreased during the 29 years from 1974 to 2002 (trend chi(2) = 19.94, P < 0.001). From 25 years of age onward, the incidence rates of the lower age groups declined with the increase of age. As for geographic distribution, the incidence rate in mountainous areas and hilly areas showed a significant declining trend in mountainous areas, chi(2) = 195.00, P < 0.001; hilly areas, chi(2) = 46.08, P < 0.001. The esophageal cancer incidence in plain areas remained steady, but had a slight increase in recent years. From 1969 to 2002, there were 18,736 cases died of esophageal cancer with 11 598 males and 7138 females. The ASR for male was 127.17 per 100,000 and 101.57 per 100,000 for female. Compared with the year 1969, the mortality rate of esophageal cancer in 2002 had a 37.96% decline. The proportion of esophageal cancer among malignant tumors in different decades decreased significantly.

CONCLUSION

The trend of the incidence rate of esophageal cancer had been decreasing for the last 29 years. The incidence rate in mountainous areas and hilly areas showed a declining trend while in the plain areas it remained steady but having slight increase in the recent years. The mortality rate of esophageal cancer had a significant decrease from 1969 to 2002.

目的

描述1974 - 2002年河北省磁县食管癌的发病率和死亡率。收集了有关比较地理、流行病学和临床研究的基本信息。

方法

20世纪70年代初，磁县建立了癌症登记系统，收集磁县所有食管癌病例的信息。数据先进行人工核对，然后计算机化、编码，并使用SPSS 11.5软件进行分析。

结果

1974年至2002年，磁县共有18471例食管癌病例，其中男性11068例，女性7403例。男性年龄标准化发病率（ASR）为每10万人208.77例，女性为每10万人120.47例。1974年至2002年的29年间，食管癌发病率呈下降趋势（趋势χ² = 19.94，P < 0.001）。从25岁起，较低年龄组的发病率随年龄增长而下降。就地理分布而言，山区和丘陵地区的发病率呈显著下降趋势，山区χ² = 195.00，P < 0.001；丘陵地区χ² = 46.08，P < 0.001。平原地区食管癌发病率保持稳定，但近年来略有上升。1969年至2002年，有18736例死于食管癌，其中男性11598例，女性7138例。男性ASR为每10万人127.17例，女性为每10万人101.57例。与1969年相比，2002年食管癌死亡率下降了37.96%。不同年代食管癌在恶性肿瘤中的比例显著下降。