Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180, Yamashiro-cho, Tokushima-city, Tokushima 770-8514, Japan.
Toxicol Appl Pharmacol. 2010 May 1;244(3):385-92. doi: 10.1016/j.taap.2010.02.012. Epub 2010 Mar 1.
Arsenic trioxide (As(2)O(3)) is widely used to treat acute promyelocytic leukemia (APL). Several lines of evidence have indicated that As(2)O(3) affects signal transduction and transactivation of transcription factors, resulting in the stimulation of apoptosis in leukemia cells, because some transcription factors are reported to associate with the redox condition of the cells, and arsenicals cause oxidative stress. Thus, the disturbance and activation of the cellular signaling pathway and transcription factors due to reactive oxygen species (ROS) generation during arsenic exposure may explain the ability of As(2)O(3) to induce a complete remission in relapsed APL patients. In this report, we review recent findings on ROS generation and alterations in signal transduction and in transactivation of transcription factors during As(2)O(3) exposure in leukemia cells.
三氧化二砷（As(2)O(3)）被广泛用于治疗急性早幼粒细胞白血病（APL）。有几条证据表明，As(2)O(3)影响信号转导和转录因子的反式激活，导致白血病细胞凋亡的刺激，因为一些转录因子据报道与细胞的氧化还原状态有关，而砷剂会引起氧化应激。因此，砷暴露时活性氧（ROS）的产生引起的细胞信号通路和转录因子的紊乱和激活可能解释了 As(2)O(3)诱导复发 APL 患者完全缓解的能力。在本报告中，我们综述了白血病细胞中 As(2)O(3)暴露时 ROS 的产生以及信号转导和转录因子反式激活的改变的最新发现。
