Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland.
Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland.
Mol Biol Rep. 2022 Oct;49(10):9929-9945. doi: 10.1007/s11033-022-07543-6. Epub 2022 May 24.
This paper aims to overview different types of stress, including DNA replication stress, oxidative stress, and psychological stress. Understanding the processes that constitute a cellular response to varied types of stress lets us find differences in how normal cells and cancer cells react to the appearance of a particular kind of stressor. The revealed dissimilarities are the key for targeting new molecules and signaling pathways in anticancer treatment. For this reason, molecular mechanisms that underlay DNA replication stress, oxidative stress, and psychological stress have been studied and briefly presented to indicate biochemical points that make stressors contribute to cancer development. What is more, the viewpoint in which cancer constitutes the outcome and the cause of stress has been taken into consideration. In a described way, this paper draws attention to the problem of cancer-related post-traumatic stress disorder and proposes a novel, multidimensional oncological approach, connecting anticancer treatment with psychiatric support.
本文旨在概述不同类型的应激，包括 DNA 复制应激、氧化应激和心理应激。了解构成细胞对各种类型应激反应的过程，使我们能够发现正常细胞和癌细胞对特定类型应激源的反应差异。所揭示的差异是在抗癌治疗中靶向新分子和信号通路的关键。出于这个原因，已经研究并简要介绍了 DNA 复制应激、氧化应激和心理应激的分子机制，以指出使应激源促进癌症发展的生化要点。更重要的是，还考虑了癌症构成应激的结果和原因的观点。本文以一种描述的方式引起了对与癌症相关的创伤后应激障碍的关注，并提出了一种新颖的、多维的肿瘤学方法，将抗癌治疗与精神支持相结合。
