攻击行为的神经生物学——与应激相关肽激素反应的自身抗体的作用
Neurobiology of Aggressive Behavior-Role of Autoantibodies Reactive With Stress-Related Peptide Hormones.
作者信息
Vaeroy Henning, Schneider Frida, Fetissov Sergueï O
机构信息
Department of Psychiatric Research, Akershus University Hospital, Nordbyhagen, Norway.
Inserm UMR1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, University of Rouen Normandy, Rouen, France.
出版信息
Front Psychiatry. 2019 Dec 4;10:872. doi: 10.3389/fpsyt.2019.00872. eCollection 2019.
Adrenocorticotropic hormone together with arginine vasopressin and oxytocin, the neuropeptides regulating the stress response and the hypothalamic-pituitary-adrenal axis activity, are known to modulate aggressive behavior. The functional role of the adrenocorticotropic hormone immunoglobulin G autoantibodies in peptidergic signaling and motivated behavior, including aggression, has been shown in experimental and models. This review summarizes some experimental data implicating autoantibodies reactive with stress-related peptides in aggressive behavior.
促肾上腺皮质激素与精氨酸加压素和催产素一起，作为调节应激反应和下丘脑-垂体-肾上腺轴活动的神经肽，已知可调节攻击行为。促肾上腺皮质激素免疫球蛋白G自身抗体在肽能信号传导和包括攻击行为在内的动机行为中的功能作用已在实验和模型中得到证实。本综述总结了一些实验数据，这些数据表明与应激相关肽反应的自身抗体与攻击行为有关。
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