重组小鼠β干扰素增强小鼠对全身性鸟分枝杆菌感染的抵抗力。
Recombinant murine beta interferon enhances resistance of mice to systemic Mycobacterium avium infection.
作者信息
Denis M
机构信息
Unité de Recherche, Hôpital Laval, Chemin Sainte-Foy, Québec, Canada.
出版信息
Infect Immun. 1991 May;59(5):1857-9. doi: 10.1128/iai.59.5.1857-1859.1991.
Abstract
Susceptible BALB/c mice were infected with Mycobacterium avium TMC 702. Groups of mice were then infused with 10(4) U (approximately 400 U/h) of murine beta interferon (IFN-beta) via a minipump system, and the progression of the infection was assessed. Mice infused with IFN-beta showed superior resistance to infection, as determined by reduced bacterial growth in the livers and spleens of infected animals, (1-log reduction in bacterial CFU at 2 months postinfection; P less than 0.001). This was corroborated by the fact that resident peritoneal macrophages treated with IFN-beta in vitro (10(2) U/ml) were more bacteriostatic for M. avium TMC 702 than their untreated counterparts. Overall, these findings suggest an important role for IFN-beta in mycobacterial infections.
摘要
将易感的BALB/c小鼠感染鸟分枝杆菌TMC 702。然后通过微型泵系统给小鼠组输注10⁴单位（约400单位/小时）的鼠β干扰素（IFN-β），并评估感染的进展。如通过感染动物肝脏和脾脏中细菌生长减少所确定的那样，输注IFN-β的小鼠对感染表现出更强的抵抗力（感染后2个月细菌CFU减少1个对数；P<0.001）。体外经IFN-β（10²单位/毫升）处理的腹腔巨噬细胞对鸟分枝杆菌TMC 702的抑菌作用强于未处理的巨噬细胞，这一事实证实了上述结果。总体而言，这些发现表明IFN-β在分枝杆菌感染中起重要作用。
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