Kjaer S K, de Villiers E M, Dahl C, Engholm G, Bock J E, Vestergaard B F, Lynge E, Jensen O M
Danish Cancer Registry, Institute of Cancer Epidemiology, Copenhagen.
Int J Cancer. 1991 Apr 22;48(1):39-44. doi: 10.1002/ijc.2910480108.
Possible risk factors for cervical cancer were investigated in 645 women, 20-49 years of age from Copenhagen, with histologically confirmed cervical cancer or carcinoma in situ and in 614 controls drawn at random from the female population of the same area. To study the role of the "male factor", monogamous cases and controls together with their husbands were invited for further examination. This included a personal interview, a blood sample for analysis of herpes simplex virus antibodies, and a penile swab for papillomavirus analysis. In total, 41 case couples and 90 control couples were enrolled (89% and 92% of eligibles, respectively). The most significant risk determinants were a history of genital warts in the male (RR = 17.9 for ever vs. never) and ever having used condoms (RR = 0.2). Other potentially important factors, although not statistically significant, were ever having visited prostitutes (RR = 2.6, p = 0.14), circumcision (RR = 0.3, p = 0.18), and a history of genital warts in the female (RR = 4.6), p = 0.09). Having a husband with a history of multiple sexual partners was also associated with an increased crude risk, but when adjustment was made for husband ever having had genital warts, use of condom, and age, no significant excess risk was observed. Human papillomavirus DNA, which was tested for with ViraPap and ViraType, was detected in one of the controls, and in only 2 case husbands. This study points to the importance of "high-risk males" for the development of cervical cancer in their sexual partner; the results support the infectious nature of the disease.
对哥本哈根645名年龄在20至49岁之间、经组织学确诊为宫颈癌或原位癌的女性，以及从同一地区女性人群中随机抽取的614名对照者，调查了宫颈癌可能的危险因素。为研究“男性因素”的作用，邀请了一夫一妻制的病例和对照者及其丈夫进行进一步检查。这包括一次个人访谈、一份用于分析单纯疱疹病毒抗体的血样，以及一份用于乳头瘤病毒分析的阴茎拭子。总共招募了41对病例夫妇和90对对照夫妇（分别占符合条件者的89%和92%）。最显著的风险决定因素是男性有生殖器疣病史（曾经有过与从未有过相比，相对危险度RR = 17.9）以及曾经使用过避孕套（RR = 0.2）。其他潜在重要因素，尽管无统计学显著性，是曾经嫖娼（RR = 2.6，p = 0.14）、包皮环切术（RR = 0.3，p = 0.18）以及女性有生殖器疣病史（RR = 4.6，p = 0.09）。丈夫有多个性伴侣史也与粗风险增加相关，但在对丈夫有生殖器疣病史、使用避孕套情况和年龄进行调整后，未观察到显著的额外风险。用ViraPap和ViraType检测人乳头瘤病毒DNA，在一名对照者以及仅两名病例的丈夫中检测到。本研究指出“高危男性”对其性伴侣患宫颈癌的重要性；结果支持该疾病的感染性本质。
