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精神分裂症基因、表观遗传学和心理神经免疫学治疗：现在都有意义了吗？

Schizophrenia genes, epigenetics and psychoneuroimmunology therapeutics: all make sense now?

机构信息

Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany.

出版信息

J Psychopharmacol. 2011 Jun;25(6):713-4. doi: 10.1177/0269881110364268. Epub 2010 Mar 1.

DOI:10.1177/0269881110364268
PMID:20194572
Abstract

Genetics, epigenetics, infection as an environmental factor, functional findings for the immune system, and a therapeutic approach with anti-inflammatory therapy provide evidence for a pivotal role of the immune system in schizophrenia. This field, therefore, should focus more on further schizophrenia research.

摘要

遗传学、表观遗传学、感染作为环境因素、免疫系统的功能发现以及抗炎治疗的治疗方法为免疫系统在精神分裂症中的关键作用提供了证据。因此，该领域应更加关注精神分裂症的进一步研究。

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引用本文的文献

[1]
Cyclooxygenase Inhibition Safety and Efficacy in Inflammation-Based Psychiatric Disorders.

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[2]
An update on the efficacy of anti-inflammatory agents for patients with schizophrenia: a meta-analysis.

Psychol Med. 2019-8-23

[3]
New drug developments in psychosis: Challenges, opportunities and strategies.

Prog Neurobiol. 2017-5

[4]
Efficacy of anti-inflammatory agents to improve symptoms in patients with schizophrenia: an update.

Schizophr Bull. 2014-1

[5]
Methylation patterns in whole blood correlate with symptoms in schizophrenia patients.

Schizophr Bull. 2014-7

[6]
The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders.

Br J Pharmacol. 2013-7

[7]
Differential age- and disease-related effects on the expression of genes related to the arachidonic acid signaling pathway in schizophrenia.

Psychiatry Res. 2012-3-6

[8]
Nonsteroidal anti-inflammatory treatment prevents delayed effects of early life stress in rats.

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