核小体重塑因子 ISWI 与一个进化上保守的细胞因子网络在功能上相互作用。
The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors.
机构信息
Dipartimento di Scienze Biochimiche, Istituto Telethon Dulbecco, Universitá degli Studi di Palermo, Palermo, Italy.
出版信息
Genetics. 2010 May;185(1):129-40. doi: 10.1534/genetics.110.114256. Epub 2010 Mar 1.
Abstract
ISWI is an evolutionarily conserved ATP-dependent chromatin remodeling factor playing central roles in DNA replication, RNA transcription, and chromosome organization. The variety of biological functions dependent on ISWI suggests that its activity could be highly regulated. Our group has previously isolated and characterized new cellular activities that positively regulate ISWI in Drosophila melanogaster. To identify factors that antagonize ISWI activity we developed a novel in vivo eye-based assay to screen for genetic suppressors of ISWI. Our screen revealed that ISWI interacts with an evolutionarily conserved network of cellular and nuclear factors that escaped previous genetic and biochemical analyses.
摘要
ISWI 是一种进化上保守的 ATP 依赖的染色质重塑因子，在 DNA 复制、RNA 转录和染色体组织中发挥核心作用。依赖于 ISWI 的多种生物学功能表明其活性可能受到高度调控。我们的研究小组之前已经在果蝇中分离并鉴定了新的细胞活性，这些活性正向调节 ISWI。为了鉴定拮抗 ISWI 活性的因子，我们开发了一种新的基于活体眼睛的筛选方法，以筛选 ISWI 的遗传抑制剂。我们的筛选揭示了 ISWI 与一个进化上保守的细胞和核因子网络相互作用，该网络逃脱了之前的遗传和生化分析。
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