Breitkreutz Bobby-Joe, Stark Chris, Reguly Teresa, Boucher Lorrie, Breitkreutz Ashton, Livstone Michael, Oughtred Rose, Lackner Daniel H, Bähler Jürg, Wood Valerie, Dolinski Kara, Tyers Mike
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada.
Nucleic Acids Res. 2008 Jan;36(Database issue):D637-40. doi: 10.1093/nar/gkm1001. Epub 2007 Nov 13.
The Biological General Repository for Interaction Datasets (BioGRID) database (http://www.thebiogrid.org) was developed to house and distribute collections of protein and genetic interactions from major model organism species. BioGRID currently contains over 198 000 interactions from six different species, as derived from both high-throughput studies and conventional focused studies. Through comprehensive curation efforts, BioGRID now includes a virtually complete set of interactions reported to date in the primary literature for both the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe. A number of new features have been added to the BioGRID including an improved user interface to display interactions based on different attributes, a mirror site and a dedicated interaction management system to coordinate curation across different locations. The BioGRID provides interaction data with monthly updates to Saccharomyces Genome Database, Flybase and Entrez Gene. Source code for the BioGRID and the linked Osprey network visualization system is now freely available without restriction.
