Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
J Clin Gastroenterol. 2010 May-Jun;44(5):335-9. doi: 10.1097/MCG.0b013e3181d34572.
The aim of this study was to investigate the therapeutic potential of cutaneous gastric electrical stimulation (CGES) at a tachygastrial frequency for obesity.
Implantable gastric electrical stimulator has been proposed for the treatment of obesity and it has recently been reported that the gastric electrical stimulation at a tachygastrial frequency inhibits gastric motility.
Ten lean and 10 obese healthy volunteers were studied in 3 randomized sessions: no CGES, CGES at the physiologic frequency (3 cycles/min), and CGES at tachygastrial frequency (12 cycles/min). Electrical stimulation was performed using sinusoidal waves. The protocol included the following sequence: 20-minute baseline, 30-minute CGES, 30-minute recording without CGES, 30-minute CGES, ingestion of a 500 kcal liquid meal, and 30-minute CGES. Gastric slow waves were recorded using cutaneous electrogastrography during the periods without CGES. Gastric emptying was assessed by ultrasound. Dyspeptic symptoms were recorded.
(1) The half-time of gastric emptying was longer with CGES at the tachygastrial frequency than CGES at the physiologic frequency in both lean subjects (75.0+/-16.5 min vs. 41.0+/-8.7 min, P<0.01) and obese subjects (64.1+/-13.3 min vs. 32.7+/-5.0 min, P<0.01). (2) Postprandial dyspeptic symptom score (mainly satiety and fullness) was significantly higher with CGES at the tachygastrial frequency than CGES at the physiologic frequency in both lean (3.2+/-1.47 vs. 1.7+/-0.94, P<0.01) and obese (3.9+/-1.89 vs. 1.8+/-1.15, P<0.01) subjects.
CGES at a tachygastrial frequency enhances postprandial fullness and satiety, and delays gastric emptying. Its therapeutic potential for obesity needs to be studied.
本研究旨在探讨快胃电刺激（CGES）在高频下治疗肥胖的治疗潜力。
植入式胃电刺激器已被提议用于治疗肥胖症，最近有报道称，高频胃电刺激可抑制胃动力。
10 名瘦人和 10 名肥胖健康志愿者在 3 次随机试验中进行研究：无 CGES、生理频率（3 次/分钟）的 CGES 和高频（12 次/分钟）的 CGES。电刺激采用正弦波。方案包括以下顺序：20 分钟基线期，30 分钟 CGES，30 分钟无 CGES 记录，30 分钟 CGES，摄入 500 千卡液体餐，30 分钟 CGES。在无 CGES 期间，使用皮肤胃电图记录胃慢波。通过超声评估胃排空。记录消化不良症状。
（1）在瘦人和肥胖受试者中，高频 CGES 的胃排空半衰期均长于生理频率 CGES（瘦人：75.0+/-16.5 分钟比 41.0+/-8.7 分钟，P<0.01；肥胖人：64.1+/-13.3 分钟比 32.7+/-5.0 分钟，P<0.01）。（2）在瘦人和肥胖受试者中，高频 CGES 的餐后消化不良症状评分（主要为饱腹感和饱胀感）均高于生理频率 CGES（瘦人：3.2+/-1.47 比 1.7+/-0.94，P<0.01；肥胖人：3.9+/-1.89 比 1.8+/-1.15，P<0.01）。
高频 CGES 可增强餐后饱腹感和饱胀感，延迟胃排空。其治疗肥胖的潜在作用需要进一步研究。
