Naproxen-associated duodenal ulcer complicated by perforation and bacteria- and barium sulfate-induced peritonitis in a dog.

Signs of abdominal pain and frequent vomiting developed in a 4-year-old dog that had been given naproxen sodium for 3 weeks. The examination included an upper gastrointestinal contrast study, using barium sulfate (BaSO4). Nine hours after barium administration, a duodenal ulcer perforated, leaking duodenal contents and BaSO4 into the peritoneal cavity. The ulcer was surgically resected, and the BaSO4 was manually removed, using saline solution-soaked gauze sponges. Treatment included peritoneal drainage and lavage every 6 hours. Recovery was without complications and the dog has not had any detectable long-term effects from peritonitis induced by BaSO4.