金（I）催化的串联环化方法合成四环吲哚啉。
Gold(I)-catalyzed tandem cyclization approach to tetracyclic indolines.
机构信息
Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, USA.
出版信息
Org Lett. 2010 Apr 2;12(7):1448-51. doi: 10.1021/ol100153h.
PMID:20196563
Abstract
Two highly stereoselective cationic gold(I)-catalyzed tandem cyclization reactions of alkynylindoles are described. These reactions demonstrated a novel and general strategy to rapidly construct highly functionalized polycyclic indolines. This approach was successfully employed for a formal synthesis of the akuammiline alkaloid minfiensine.
摘要
本文描述了两种高度对映选择性的阳离子金（I）催化的炔基吲哚串联环化反应。这些反应展示了一种新颖而通用的策略，可以快速构建高度官能化的多环吲哚啉。该方法成功地应用于阿枯米林生物碱米芬辛的形式合成。
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