一锅法合成 11H-吲哚并[3,2-c]喹啉的金催化方法。
An alternative one-pot gold-catalyzed approach to the assembly of 11H-indolo[3,2-c]quinolines.
机构信息
Dipartimento di Scienze Farmaceutiche-Sezione di Chimica generale e Organica A. Marchesini, Università degli Studi di Milano, Via G. Venezian 21, 20133 Milano, Italy.
出版信息
Org Biomol Chem. 2012 Oct 14;10(38):7801-8. doi: 10.1039/c2ob26380g.
PMID:22911041
Abstract
A new one-pot approach was developed to construct the 11H-indolo[3,2-c]quinoline scaffold through a gold-catalysed reaction of 2-[(2-aminophenyl)ethynyl]phenylamine derivatives with aldehydes. The broad scope and the high regioselectivity of this new protocol as well as the mild and neutral reaction conditions make it a viable alternative to the previously reported procedures.
摘要
开发了一种新的一锅法，通过金催化 2-[(2-氨基苯基)乙炔基]苯胺衍生物与醛的反应，构建 11H-吲哚并[3,2-c]喹啉骨架。该新方法具有广泛的适用范围和高度的区域选择性，以及温和、中性的反应条件，使其成为以前报道的方法的可行替代方法。
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