State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 18 Tianshui Middle Road, Lanzhou 730000, China.
J Am Chem Soc. 2010 Mar 24;132(11):3650-1. doi: 10.1021/ja910104n.
An efficient protocol for the generation of amines by palladium-catalyzed nucleophilic benzylic addition of 2-methyl-substituted azaarenes to N-sulfonyl aldimines under neutral conditions via C-H bond activation has been developed. This reaction represents a very efficient methodology for the synthesis of heterocycle-containing amines and thus opens a new way to access amines through C-H bond activation.
开发了一种通过 C-H 键活化，在中性条件下钯催化 2-甲基取代氮杂芳烃与 N-磺酰基亚胺的亲核苄基加成反应高效制备胺的方法。该反应为合成含杂环胺提供了一种非常有效的方法，从而为通过 C-H 键活化来制备胺开辟了新途径。
