Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Org Lett. 2011 Apr 1;13(7):1706-9. doi: 10.1021/ol200217y. Epub 2011 Mar 3.
A Lewis acid catalyzed benzylic C-H bond functionalization of alkyl-substituted azaarenes is described. Sc(OTf)(3) and Y(OTf)(3) promoted the direct addition of alkyl-substituted azaarenes and benzoxazole to enones and an α,β-unsaturated N-acylpyrrole. Products were obtained in 60-96% yield.
本文描述了一种路易斯酸催化的烷基取代氮杂芳烃的苄位 C-H 键功能化反应。Sc(OTf)3 和 Y(OTf)3 促进了烷基取代氮杂芳烃和苯并恶唑与烯酮和α,β-不饱和 N-酰基吡咯的直接加成。产物的收率为 60-96%。
