Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, University of Science and Technology of China, Hefei, 230026, P. R. China.
J Org Chem. 2011 Aug 19;76(16):6849-55. doi: 10.1021/jo2008934. Epub 2011 Jul 22.
A highly efficient synthesis of trans-alkenylazaarene under catalyst-free conditions was developed via the addition of methylazaarenes to N-sulfonyl aldimines and a subsequent C-N elimination in situ. A one-pot procedure for this addition-elimination was also developed. The reaction could tolerate a broad substrate scope and give the corresponding alkenylazaarenes in high yields.
在无催化剂条件下，通过甲基氮杂芳烃与 N-磺酰基亚胺的加成以及随后的原位 C-N 消除，高效合成了反式烯基氮杂芳烃。还开发了这种加成-消除的一锅法程序。该反应可以耐受广泛的底物范围，并以高产率得到相应的烯基氮杂芳烃。
