Center for Liver Diseases Outcomes Research Program, Inova Fairfax Hospital, Betty and Guy Beatty Center for Integrated Research, Falls Church, VA, USA.
J Viral Hepat. 2011 Jan;18(1):70-6. doi: 10.1111/j.1365-2893.2010.01278.x.
Asian Americans represent an important cohort at high risk for viral hepatitis. To determine the prevalence of Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infection and HBV vaccination in a Vietnamese community, a total of 322 Vietnamese subjects from a local doctor's office and annual Vietnamese Health Fair were included in this study. Demographic and clinical data were collected. 2.2% of the screened cohort tested positive for anti-HCV and 9.3% tested positive for HBsAg. Unlike HBV-positive subjects, HCV-positive subjects had significantly higher liver enzymes (P = 0.0045 and P = 0.0332, respectively). The HBV-positive group was more likely to report jaundice (P = 0.0138) and a family history of HBV (P = 0.0115) compared to HBV-negative subjects. Forty-eight patients (15.5%) reported a family history of liver disease (HBV, HCV, HCC, cirrhosis, other). Of this 48, 68.8% reported no personal history of HBV vaccination and 77.1% reported no family history of vaccination for HBV. Among the 183 subjects without a family history of liver disease, 156 (85.2%) reported no personal history of vaccination and 168 (91.8%) reported no family history of vaccination. HBV vaccination rates in those reporting a family history of liver disease were significantly higher (P =0.020). There was a high prevalence of HBV infection in this community screening. Nevertheless, the rate for HBV vaccination was low. The low prevalence of abnormal liver enzymes in HBV-positive subjects emphasizes the need for screening to be triggered by risk factors and not by abnormal liver enzymes.
亚裔美国人是感染病毒性肝炎的高危人群之一。为了确定越南人群中乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染以及乙型肝炎病毒（HBV）疫苗接种的流行率，本研究共纳入了当地医生办公室和年度越南健康博览会上的 322 名越南人。收集了人口统计学和临床数据。在筛查出的队列中，有 2.2%的人抗 HCV 检测呈阳性，9.3%的人 HBsAg 检测呈阳性。与 HBV 阳性者相比，HCV 阳性者的肝酶明显更高（分别为 P = 0.0045 和 P = 0.0332）。HBV 阳性组更有可能报告黄疸（P = 0.0138）和 HBV 家族史（P = 0.0115），而 HBV 阴性组则没有。48 名患者（15.5%）报告有家族性肝病史（HBV、HCV、HCC、肝硬化、其他）。在这 48 名患者中，68.8%报告没有 HBV 疫苗接种个人史，77.1%报告没有 HBV 疫苗接种家族史。在没有家族性肝病史的 183 名患者中，156 名（85.2%）报告没有个人疫苗接种史，168 名（91.8%）报告没有家族疫苗接种史。报告有家族性肝病史的患者的 HBV 疫苗接种率明显更高（P = 0.020）。在本次社区筛查中，HBV 感染的流行率很高。然而，HBV 疫苗接种率却很低。HBV 阳性者中异常肝酶的低发生率强调了需要根据危险因素而不是异常肝酶来触发筛查。
