Waqar Salman, Simcock Peter
West of England Eye Unit, Royal Devon and Exeter NHS Hospital, Barrack Road, Exeter, Devon, EX2 5DS, UK.
J Med Case Rep. 2010 Mar 2;4:77. doi: 10.1186/1752-1947-4-77.
The use of alpha-1a receptor antagonists (tamsulosin) is widely accepted in the treatment of benign prostatic hypertrophy (BPH). It has previously been implicated as a causative agent in intra-operative floppy iris syndrome due to its effects on the smooth muscle. We report a case of lower lid entropion that may be related to a patient commencing treatment of tamsulosin.
A 74-year-old Caucasian man was started on alpha 1-a receptor antagonist (Tamsulosin) treatment for benign prostatic hypertrophy. Eight days later, he presented to the ophthalmology unit with a right lower lid entropion which was successfully treated surgically with a Weiss procedure.
We report a case of lower lid entropion that may be secondary to the recent use of an alpha-1a blocker (tamsulosin). This can be explained by considering the effect of autonomic blockade on alpha-1 receptors in the Muller's muscle on a patient that may already have an anatomical predisposition to entropion formation due to a further reduction in muscle tone.
α-1a受体拮抗剂（坦索罗辛）在良性前列腺增生（BPH）的治疗中已被广泛应用。由于其对平滑肌的作用，它之前被认为是术中虹膜松弛综合征的致病因素。我们报告一例下睑内翻病例，可能与患者开始使用坦索罗辛治疗有关。
一名74岁的白种男性开始使用α1-a受体拮抗剂（坦索罗辛）治疗良性前列腺增生。八天后，他因右下睑内翻就诊于眼科，通过Weiss手术成功进行了手术治疗。
我们报告一例下睑内翻病例，可能继发于近期使用α-1a阻滞剂（坦索罗辛）。考虑到自主神经阻滞对米勒肌中α-1受体的影响，对于一名可能因肌张力进一步降低而已有内翻形成解剖学易患因素的患者，这一情况可以得到解释。
