沙特阿拉伯马迪纳急性胃肠炎患儿中冠状病毒的检测
Detection of coronaviruses in children with acute gastroenteritis in Maddina, Saudi Arabia.
作者信息
Kheyami A M, Nakagomi T, Nakagomi O, Getty B, Hart C A, Cunliffe N A
机构信息
Division of Medical Microbiology, University of Liverpool, Daulby Street, Liverpool, UK.
出版信息
Ann Trop Paediatr. 2010;30(1):45-50. doi: 10.1179/146532810X12637745451997.
BACKGROUND
The role of coronaviruses in paediatric gastro-enteritis is not well defined. We investigated the detection rate and epidemiological features of infection with coronavirus in children receiving hospital care for acute gastro-enteritis in Maddina, Saudi Arabia.
METHODS
Stool specimens were collected from children less than 5 years of age who were either hospitalised in Maddina or given oral rehydration therapy as outpatients between April 2004 and April 2005. Coronaviruses were detected by electron microscopy.
RESULTS
Coronaviruses were detected in 63 (6%) of 984 children with acute gastro-enteritis and were more commonly detected in outpatients (47/423, 11%) than in inpatients (16/561, 3%). The median age (range) of children with coronavirus infection was 42 months (10-60). Coronaviruses were detected throughout the year with the highest detection rate at the end of the winter season.
CONCLUSIONS
Coronaviruses were commonly identified in children with diarrhoea in Saudi Arabia. Their role in paediatric gastro-enteritis warrants further evaluation.
背景
冠状病毒在小儿胃肠炎中的作用尚不明确。我们调查了沙特阿拉伯麦加接受急性胃肠炎住院治疗的儿童中冠状病毒感染的检出率及流行病学特征。
方法
收集了2004年4月至2005年4月期间在麦加住院或作为门诊接受口服补液治疗的5岁以下儿童的粪便标本。通过电子显微镜检测冠状病毒。
结果
984例急性胃肠炎儿童中有63例（6%）检测出冠状病毒，门诊患者（47/423，11%）的检出率高于住院患者（16/561，3%）。冠状病毒感染儿童的中位年龄（范围）为42个月（10 - 60个月）。全年均检测到冠状病毒，冬季末检出率最高。
结论
在沙特阿拉伯腹泻儿童中常见冠状病毒感染。它们在小儿胃肠炎中的作用值得进一步评估。
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