State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Acta Biomater. 2010 Aug;6(8):3199-207. doi: 10.1016/j.actbio.2010.02.049. Epub 2010 Mar 1.
A bismuth-doped injectable calcium phosphate cement (BD-ICPC) with improved radiopacity, potent antimicrobial activity and sealability was developed by introducing bismuth salicylate basic (BSB) into the powder phase of the calcium phosphate cement (CPC). The results showed that the radiopacity and sealability of BD-ICPC were improved compared with pure ICPC. Although BSB had a retarding effect on the setting rate of the cement, the addition of BSB reduced the viscosity and yield stress of BD-ICPC, thus enhanced its injectability. It was noteworthy that BD-ICPC had a potent antimicrobial activity with improved sealability. In addition, BD-ICPC afforded a uniform and tight adaptation to the root canal wall. These results indicate that BD-ICPC possesses a combination of good in vitro radiopacity, high injectability, potent antimicrobial activity, improved sealability and tight adaptation to the root canal. It is expected to be used as a novel root canal filling material.
一种新型的铋掺杂可注射磷酸钙骨水泥（BD-ICPC），兼具良好的 X 射线阻射性、高效的抗菌活性和良好的密封性，是通过将水杨酸铋（BSB）引入磷酸钙骨水泥（CPC）的粉末相中制备得到的。研究结果表明，与纯 ICPC 相比，BD-ICPC 的 X 射线阻射性和密封性得到了提高。虽然 BSB 对水泥的凝固速率有延迟作用，但添加 BSB 降低了 BD-ICPC 的粘度和屈服应力，从而提高了其可注射性。值得注意的是，BD-ICPC 具有高效的抗菌活性和良好的密封性。此外，BD-ICPC 可以均匀且紧密地适应根管壁。这些结果表明，BD-ICPC 具有良好的体外 X 射线阻射性、高可注射性、高效的抗菌活性、良好的密封性和与根管紧密的适应性。有望成为一种新型的根管填充材料。
