Nguyen Ngoc Huu, Lu Zufu, Elbourne Aaron, Vasilev Krasimir, Roohani Iman, Zreiqat Hala, Truong Vi Khanh
School of Biomedical Engineering, The University of Sydney, Camperdown, NSW, 2006, Australia.
Biomedical Nanoengineering Laboratory, College of Medicine and Public Health, Flinders University, Bedford Park SA 5042, Australia.
Mater Today Bio. 2024 Apr 27;26:101069. doi: 10.1016/j.mtbio.2024.101069. eCollection 2024 Jun.
The urgency to address skeletal abnormalities and diseases through innovative approaches has led to a significant interdisciplinary convergence of engineering, 3D printing, and design in developing individualised bioceramic bioscaffolds. This review explores into the recent advancements and future trajectory of non-antibiotic antibacterial bioceramics in bone tissue engineering, an importance given the escalating challenges of orthopaedic infections, antibiotic resistance, and emergent pathogens. Initially, the review provides an in-depth exploration of the complex interactions among bacteria, immune cells, and bioceramics in clinical contexts, highlighting the multifaceted nature of infection dynamics, including protein adsorption, immunological responses, bacterial adherence, and endotoxin release. Then, focus on the next-generation bioceramics designed to offer multifunctionality, especially in delivering antibacterial properties independent of traditional antibiotics. A key highlight of this study is the exploration of smart antibacterial bioceramics, marking a revolutionary stride in medical implant technology. The review also aims to guide the ongoing development and clinical adoption of bioceramic materials, focusing on their dual capabilities in promoting bone regeneration and exhibiting antibacterial properties. These next-generation bioceramics represent a paradigm shift in medical implant technology, offering multifunctional benefits that transcend traditional approaches.
通过创新方法解决骨骼异常和疾病的紧迫性，促使工程学、3D打印和设计在开发个性化生物陶瓷生物支架方面实现了显著的跨学科融合。本综述探讨了非抗生素抗菌生物陶瓷在骨组织工程中的最新进展和未来发展轨迹，鉴于骨科感染、抗生素耐药性和新出现病原体带来的挑战不断升级，这一点至关重要。首先，该综述深入探讨了临床环境中细菌、免疫细胞和生物陶瓷之间的复杂相互作用，强调了感染动态的多面性，包括蛋白质吸附、免疫反应、细菌黏附和内毒素释放。然后，重点关注旨在提供多功能性的下一代生物陶瓷，特别是在提供独立于传统抗生素的抗菌性能方面。这项研究的一个关键亮点是对智能抗菌生物陶瓷的探索，这标志着医疗植入技术的一次革命性飞跃。该综述还旨在指导生物陶瓷材料的持续开发和临床应用，重点关注其促进骨再生和展现抗菌性能的双重能力。这些下一代生物陶瓷代表了医疗植入技术的范式转变，提供了超越传统方法的多功能益处。
