Department of Pathology, University of Melbourne, Parkville, Vic., 3010, Australia.
Vaccine. 2010 May 14;28(22):3865-73. doi: 10.1016/j.vaccine.2010.02.073. Epub 2010 Mar 1.
Immunomodulation by plant-derived medicines is well-documented with effects on both innate and adaptive immunity. This study reports potent and long-lasting diphtheria toxoid-specific immunity by the botanical medicinal, Rehmannia Six Formula, using an in vivo mouse model of vaccine immunity. A significant vaccine adjuvant effect was observed with an increase in serum anti-diphtheria toxoid total and IgG antibodies following oral administration of Rehmannia Six Formula to mice. This response was antigen-specific and was still detectable six months following botanical medicinal treatment, suggesting that Rehmannia Six Formula could help maintain protective antibody levels in populations where vaccine coverage is low. Rehmannia Six Formula was well-tolerated with no adverse effects on mouse weight or survival observed in this study and suggests a potential role as a novel vaccine adjuvant preparation.
植物药的免疫调节作用已有充分的文献记载，对先天免疫和适应性免疫都有影响。本研究报告了一种植物药——地黄六方，在体内疫苗免疫的小鼠模型中，具有强大而持久的白喉类毒素特异性免疫作用。通过口服地黄六方，观察到血清抗白喉类毒素总抗体和 IgG 抗体显著增加，具有显著的疫苗佐剂作用。这种反应是抗原特异性的，在植物药治疗六个月后仍能检测到，这表明地黄六方可能有助于维持疫苗覆盖率低的人群中的保护性抗体水平。地黄六方耐受性良好，在本研究中未观察到对小鼠体重或生存的不良影响，提示其可能作为一种新型疫苗佐剂制剂发挥作用。
