Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Simancas 47130, Valladolid, Spain.
Metabolism. 2011 Feb;60(2):272-6. doi: 10.1016/j.metabol.2010.01.028. Epub 2010 Mar 2.
A silent polymorphism (1359 G/A) of the cannabinoid receptor gene was reported as a common polymorphism in white populations. The aim of our study was to investigate the influence of this polymorphism (G1359A) of cannabinoid receptor gene on obesity, insulin resistance, and adipocytokines in women with obesity. A population of 290 women was analyzed. Indirect calorimetry, tetrapolar electrical bioimpedance, blood pressure measurement, serial assessment of nutritional intake with 3-day written food records, and biochemical analysis were performed. One hundred fifty-nine patients (54.8%) had the genotype G1359G (wild-type group), and 131 (45.2%) patients had G1359A (116 patients, 40.0%) or A1359A (15 patients, 5.2%) (mutant-type group). Triglycerides (122.3 ± 65.9 vs 107.2 ± 44.8 mg/dL, P < .05), insulin (15.8 ± 9.4 vs 13.6 ± 6.9 mUI/L, P < .05), and homeostasis model assessment values (3.85 ± 2.2 vs 3.33 ± 1.9, P < .05) were higher in the wild-type group than the mutant-type group. High-density lipoprotein cholesterol levels (56.8 ± 24.1 vs 58.3 ± 13.9 mg/dL, P < .05) were higher in the mutant-type group than the wild-type group. The novel finding of this study is the association of the mutant-type group G1359A and A1359A with a better cardiovascular profile (triglyceride, high-density lipoprotein cholesterol, insulin, and homeostasis model assessment levels) than the wild-type group.
一项研究报道，大麻素受体基因的一个沉默多态性（1359G/A）是白种人群中的常见多态性。本研究旨在探讨大麻素受体基因的这种多态性（G1359A）对肥胖女性的肥胖、胰岛素抵抗和脂肪细胞因子的影响。分析了 290 名女性。进行了间接热量测定、四极电生物阻抗、血压测量、3 天书面食物记录的连续营养摄入评估以及生化分析。159 例患者（54.8%）的基因型为 G1359G（野生型组），131 例患者（45.2%）的基因型为 G1359A（116 例，40.0%）或 A1359A（15 例，5.2%）（突变型组）。野生型组的甘油三酯（122.3 ± 65.9 与 107.2 ± 44.8 mg/dL，P <.05）、胰岛素（15.8 ± 9.4 与 13.6 ± 6.9 mUI/L，P <.05）和稳态模型评估值（3.85 ± 2.2 与 3.33 ± 1.9，P <.05）均高于突变型组。突变型组的高密度脂蛋白胆固醇水平（56.8 ± 24.1 与 58.3 ± 13.9 mg/dL，P <.05）高于野生型组。本研究的新发现是，突变型组 G1359A 和 A1359A 与更好的心血管特征（甘油三酯、高密度脂蛋白胆固醇、胰岛素和稳态模型评估值）相关，优于野生型组。
