Center of Investigation of Endocrinology and Clinical Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Simancas, Valladolid, Spain.
Diabetes Metab Res Rev. 2011 Jul;27(5):506-11. doi: 10.1002/dmrr.1200.
A polymorphism (1359 G/A) of the cannabinoid type-1 receptor gene was reported as a common polymorphism in Caucasian populations. Some metabolic disorders are related to this polymorphism.
The aim of our study was to investigate the association between metabolic syndrome and this polymorphism.
A population of 917 obese patients was analysed in a cross-sectional survey. Bioimpedance, blood pressure, an assessment of nutritional intake and biochemical analysis were recorded.
Five hundred and twelve patients (55.8%) had the genotype G1359G (wild-type group), whereas 344 (37.5%) had genotype G1359A and 61 (6.7%) patients had A1359A. (G1359A and A1359A were included in the mutant-type group; 44.2% total). In wild type patients, metabolic syndrome prevalence was higher (54.9% versus 45.1%; p < 0.05) than no metabolic syndrome prevalence. In patients with mutant genotypes, metabolic syndrome prevalence was lower (43.7% versus 56.3%; p < 0.05). Glucose, insulin and homeostasis model assessment levels were higher in patients with the wild genotype than in those with the mutant type. Adiponectin levels were lower in patients with the wild genotype than in those with the mutant type.
The novel finding of this study is the association of the G1359A and A1359A cannabinoid type-1 genotypes with a lower prevalence of metabolic syndrome than the G1359G genotype.
大麻素 1 型受体基因的一种多态性（1359 G/A）被报道为白种人群中的常见多态性。一些代谢紊乱与这种多态性有关。
我们的研究旨在探讨代谢综合征与这种多态性之间的关系。
在一项横断面研究中分析了 917 名肥胖患者的人群。记录了生物阻抗、血压、营养摄入评估和生化分析。
512 名患者（55.8%）具有 G1359G 基因型（野生型组），344 名（37.5%）具有 G1359A 基因型，61 名（6.7%）患者具有 A1359A 基因型。（G1359A 和 A1359A 被包括在突变型组中；总计 44.2%）。在野生型患者中，代谢综合征的患病率更高（54.9%比 45.1%；p<0.05），而代谢综合征的患病率更低（43.7%比 56.3%；p<0.05）。具有野生型基因型的患者的葡萄糖、胰岛素和稳态模型评估水平高于具有突变型基因型的患者。具有野生型基因型的患者的脂联素水平低于具有突变型基因型的患者。
本研究的新发现是，大麻素 1 型受体基因的 G1359A 和 A1359A 基因型与代谢综合征的患病率低于 G1359G 基因型有关。
