用于引导细胞反应的模块化自组装生物材料。
Modular self-assembling biomaterials for directing cellular responses.
作者信息
Collier Joel H
机构信息
Joel H. Collier, Ph.D., Assistant Professor, Department of Surgery and Committee on Molecular Medicine, University of Chicago, 5841 S. Maryland Ave, Abbott Hall AB522, Chicago, IL 60637 USA,
出版信息
Soft Matter. 2008;4(12):2310-2315. doi: 10.1039/b805563g.
Self-assembling biomaterials are promising as cell-interactive matrices because they can be constructed in a modular fashion, which enables the independent and simultaneous tuning of several of their physicochemical and biological properties. Such modularity facilitates the optimization of multi-component matrices for use in complex biological environments such as 3-D cell culture or scaffolds for regenerative medicine. This Highlight will discuss recent strategies for producing modular self-assembling biomaterials, with a particular focus on how ligand presentation and matrix mechanics can be controlled in modular ways. In addition, it will discuss key hurdles that remain for employing these materials as cell-interactive scaffolds in biomedical applications, particularly those that relate to how they may interface with the immune system.
自组装生物材料作为细胞相互作用基质具有广阔前景，因为它们可以以模块化方式构建，这使得能够独立且同时调节其多种物理化学和生物学特性。这种模块化有助于优化用于复杂生物环境（如三维细胞培养或再生医学支架）的多组分基质。本综述将讨论生产模块化自组装生物材料的最新策略，特别关注如何以模块化方式控制配体呈现和基质力学。此外，还将讨论在生物医学应用中将这些材料用作细胞相互作用支架时仍然存在的关键障碍，特别是那些与它们如何与免疫系统相互作用相关的障碍。
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