Rasale Dnyaneshwar B, Das Apurba K
Department of Chemistry, Indian Institute of Technology Indore, Khandwa Road, Indore 452017, India.
Int J Mol Sci. 2015 May 13;16(5):10797-820. doi: 10.3390/ijms160510797.
Fabrication of self-assembled nanostructures is one of the important aspects in nanoscience and nanotechnology. The study of self-assembled soft materials remains an area of interest due to their potential applications in biomedicine. The versatile properties of soft materials can be tuned using a bottom up approach of small molecules. Peptide based self-assembly has significant impact in biology because of its unique features such as biocompatibility, straight peptide chain and the presence of different side chain functionality. These unique features explore peptides in various self-assembly process. In this review, we briefly introduce chemical reaction-mediated peptide self-assembly. Herein, we have emphasised enzymes, native chemical ligation and photochemical reactions in the exploration of peptide self-assembly.
自组装纳米结构的制备是纳米科学和纳米技术的重要方面之一。由于自组装软材料在生物医学中的潜在应用，对其研究仍然是一个备受关注的领域。软材料的多种特性可以通过小分子的自下而上方法进行调控。基于肽的自组装因其生物相容性、直肽链和不同侧链功能等独特特征而在生物学中具有重要影响。这些独特特征在各种自组装过程中探索肽。在本综述中，我们简要介绍化学反应介导的肽自组装。在此，我们强调了酶、天然化学连接和光化学反应在肽自组装探索中的作用。
