一种小分子受体，能够以类似于天然蛋白质的亲和力选择性地识别组蛋白肽中的三甲基赖氨酸。
A small molecule receptor that selectively recognizes trimethyl lysine in a histone peptide with native protein-like affinity.
机构信息
Department of Chemistry, CB 3290, University of North Carolina, Chapel Hill, NC 27599, USA.
出版信息
Chem Commun (Camb). 2010 Mar 21;46(11):1839-41. doi: 10.1039/c000255k. Epub 2010 Feb 12.
DOI:10.1039/c000255k
PMID:20198226
Abstract
A small molecule receptor that mimics the HP1 chromodomain's affinity for trimethyl lysine has been identified from a dynamic combinatorial library. Discrimination for trimethyl lysine over the lower methylation states parallels that of the native protein receptor. These studies demonstrate the feasibility of small molecule receptors as potential sensors for protein post-translational modifications.
摘要
一种小分子受体已从动态组合文库中被鉴定出来，它模拟了 HP1 染色质结构域对三甲基赖氨酸的亲和力。对三甲基赖氨酸的选择性识别优于较低的甲基化状态，与天然蛋白受体相似。这些研究证明了小分子受体作为蛋白质翻译后修饰潜在传感器的可行性。
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