Department of Laboratory Medicine, Mie University School of Medicine, Tsu, Mie 514-8507, Japan.
Int J Mol Med. 2010 Apr;25(4):601-6. doi: 10.3892/ijmm_00000382.
Patterns of hypocholesterolemic lipid fractions in 295 patients with liver diseases, malignant tumors, arteriosclerotic and renal diseases with cholesterol (Chol) levels of <30 mg/dl were classified using a simultaneous analytical method for the Chol and triglyceride (TG) fractions (Chol/Trig Combo System). Hypocholesterolemia was classified as follows: IV, Type IV on WHO hyperlipidemia phenotype classification; intermediate density lipoprotein (IDL), cases with appearance of IDL, including appearance of Lp(a); high + low density lipoproteins (HDL+LDL), lipids mostly consisting of HDL and LDL fractions; HDL abnormality, cases with slow alphaHDL or fast HDL; abnormal LDL, both Chol and TG fractions mostly consisting of LDL fraction; normal type, ratios of HDL, very low density lipoproteins (VLD) and LDL fractions were almost normal; and low HDL, HDL-C was <30 mg/dl. Many patients with liver diseases had HDL+LDL (45%), and abnormal LDL was noted in 13% of the cases. In malignant tumors, the frequencies of low HDL, normal type, and HDL+LDL cases were similar (22-30%). In arteriosclerosis, normal type accounted for 46% of the cases, and the frequency of normal type was higher (60%) in renal diseases. Mortality rate (within 1 year after measurement) was then compared among lipid patterns. In liver diseases, mortality rate increased in the following order: abnormal LDL (55%); low HDL (31%); HDL abnormality (25%); and HDL+LDL (21%). No deaths were seen among patients with normal type. In malignant tumors, mortality rate was very high (88%) in patients with HDL+LDL, but low in patients with normal type (22%) and low HDL (9%). Mortality rate was low in patients with arteriosclerosis and renal diseases in the short-term follow-up period (1 year). In the comparisons of distribution, mean, and appearance rate of charge modification frequency (CMF) among lipid patterns, parameters were high in all patterns other than HDL+LDL. Classification of hypocholesterolemia lipid patterns and evaluation of CMF may therefore be clinically useful.
295 例胆固醇（Chol）水平<30mg/dl 的肝病、恶性肿瘤、动脉硬化和肾病患者的血脂部分的低胆固醇血症模式，采用 Chol 和三酰甘油（TG）部分的同时分析方法（Chol/Trig Combo System）进行分类。低胆固醇血症分类如下：根据世界卫生组织（WHO）高脂血症表型分类为 IV 型和 IV 型；中间密度脂蛋白（IDL），出现 IDL 的病例，包括出现 Lp(a)；高+低密脂蛋白（HDL+LDL），主要由 HDL 和 LDL 部分组成的脂质；HDL 异常，慢αHDL 或快 HDL 的病例；异常 LDL，Chol 和 TG 部分主要由 LDL 部分组成；正常型，HDL、极低密度脂蛋白（VLD）和 LDL 部分的比例基本正常；低 HDL，HDL-C<30mg/dl。许多肝病患者有 HDL+LDL（45%），13%的病例有异常 LDL。在恶性肿瘤中，低 HDL、正常型和 HDL+LDL 病例的频率相似（22-30%）。在动脉硬化中，正常型占 46%，肾病中正常型的频率更高（60%）。然后比较了不同血脂模式的死亡率（测量后 1 年内）。在肝病中，死亡率按以下顺序增加：异常 LDL（55%）；低 HDL（31%）；HDL 异常（25%）；HDL+LDL（21%）。正常型患者无死亡。在恶性肿瘤中，HDL+LDL 患者的死亡率非常高（88%），而正常型（22%）和低 HDL（9%）患者的死亡率较低。在短期随访期间（1 年），动脉硬化和肾病患者的死亡率较低。在血脂模式之间的电荷修饰频率（CMF）分布、平均值和出现率的比较中，除了 HDL+LDL 之外，所有模式的参数都较高。低胆固醇血症血脂模式的分类和 CMF 的评估因此可能具有临床意义。
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