Svanström Caroline, Lonne-Rahm Sol-Britt, Nordlind Klas
Department of Dermatology, Mälarsjukhuset, Eskilstuna, Sweden.
Department of Medicine, Solna, Dermatology and Venereology Unit, Karolinska Institutet, Stockholm, Sweden.
Psoriasis (Auckl). 2019 Aug 21;9:75-79. doi: 10.2147/PTT.S164104. eCollection 2019.
Psoriasis is a chronic inflammatory skin disease that may be triggered or worsened by several factors, including alcohol. A higher than average alcohol consumption is common among individuals with psoriasis. Neurobiological signaling affected by alcohol intake includes a range of neurotransmitters, such as the dopaminergic, serotonergic, and tachykinergic systems, involved in reward and drug-seeking. These neurotransmitters may also have an impact on the inflammatory processes per se in psoriasis. Future therapy may, therefore, be targeted at neurotransmitter networks involved with both alcohol intake and the inflammatory processes.
银屑病是一种慢性炎症性皮肤病,可能由多种因素引发或加重,包括酒精。银屑病患者中饮酒量高于平均水平的情况很常见。受酒精摄入影响的神经生物学信号传导包括一系列神经递质,如多巴胺能、血清素能和速激肽能系统,这些系统参与奖赏和觅药行为。这些神经递质也可能对银屑病本身的炎症过程产生影响。因此,未来的治疗可能针对与酒精摄入和炎症过程相关的神经递质网络。