Department of Neurology and Nuclear Medicine, Rabin Medical Center, Petah Tiqwa, Israel.
Mov Disord. 2010 May 15;25(7):924-7. doi: 10.1002/mds.23030.
Lower leg rest tremor is an uncommon symptom of neurological disease. Review of the files of 16 patients who presented with lower leg tremor (average age 58 +/- 16 years; average disease duration 6.8 +/- 8.5 years) yielded a diagnosis of Parkinson's disease (PD) in 5 and probable multiple system atrophy (MSA) in 3. In 4 patients with an indeterminate diagnosis, cardiac MIBG SPECT was positive in 3, indicating PD, and negative in one, suggesting MSA. Two patients each had psychogenic tremor and drug-induced parkinsonism. Although lower leg tremor is considered an unusual presentation of PD, it should raise suspicions of MSA and other neurodegenerative disorders.
小腿震颤是一种罕见的神经疾病症状。对 16 名出现小腿震颤患者的档案进行回顾（平均年龄 58 +/- 16 岁；平均病程 6.8 +/- 8.5 年），5 名患者被诊断为帕金森病（PD），3 名患者被诊断为可能的多系统萎缩（MSA）。在 4 名诊断不确定的患者中，3 名患者的心脏 MIBG SPECT 呈阳性，提示 PD，1 名患者呈阴性，提示 MSA。2 名患者分别患有心因性震颤和药物诱导性帕金森病。尽管小腿震颤被认为是 PD 的一种不常见表现，但它应该引起对 MSA 和其他神经退行性疾病的怀疑。
