School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Int J Neurosci. 2010 Feb;120(2):150-4. doi: 10.3109/00207450903316527.
We studied cerebral effects of complementary acupuncture in Parkinson's disease using single photon emission computed tomography (SPECT) measures of 99mTc-ECD and 99mTc-TRODAT-4, before and after five weeks of treatment. Ten patients were randomly assigned to receive levodopa alone (controls) or levodopa and complementary scalp electro-acupuncture. Before treatment, no hemispheric regional cerebral blood flow (rCBF) differences were found, whereas striatal dopamine transporter (DAT) activity was lower in the most affected hemisphere. Treatment with levodopa alone did not change rCBF, whereas it increased basal ganglion DAT activity in the most affected hemisphere. Patients who received levodopa and complementary acupuncture had increased rCBF in the frontal lobe, the occipital lobe, the basal ganglion, and the cerebellum in the most affected hemisphere as compared to baseline, but there were no changes in basal ganglia DAT levels. Thus, complementary acupuncture treatment in Parkinson's disease may affect rCBF but not basal ganglion DAT.
我们使用单光子发射计算机断层扫描（SPECT）测量 99mTc-ECD 和 99mTc-TRODAT-4，研究了帕金森病的补充针灸对大脑的影响，分别在治疗前和治疗后 5 周进行了测量。10 名患者被随机分配接受左旋多巴单独治疗（对照组）或左旋多巴和头皮电针补充治疗。治疗前，未发现半球局部脑血流（rCBF）差异，而受累半球纹状体多巴胺转运蛋白（DAT）活性较低。单独使用左旋多巴治疗不会改变 rCBF，但会增加受累半球基底节 DAT 活性。与基线相比，接受左旋多巴和补充针灸的患者受累半球额叶、枕叶、基底节和小脑的 rCBF 增加，但基底节 DAT 水平没有变化。因此，帕金森病的补充针灸治疗可能会影响 rCBF，但不会影响基底节 DAT。
