Superior NanoBioSystems LLC, 11722 Newbridge Court, Reston, VA, 20191, USA.
Curr Pharm Biotechnol. 2010 Jun;11(4):366-75. doi: 10.2174/138920110791233316.
There are conditions in clinical medicine demanding critical therapeutic decisions. These conditions necessitate accuracy, rapidity, accessibility, cost-effectiveness and mobility. New technologies have been developed in order to address these challenges. Microfluidics and Micro Electro-Mechanical Systems are two of such technologies. Microfluidics, a discipline that involves processing fluids at the microscale in etched microchannels, is being used to build lab- on-a-chip systems to run chemical and biological assays. These systems are being transformed into handheld devices designed to be used at remote settings or at the bedside. MEMS are microscale electromechanical elements integrated in lab chip systems or used as individual components. MEMS based sensors represents a highly developed field with successful commercialized products currently being incorporated into vitro,ex vivo and in vivo devices. In the present paper several examples of microfluidic devices and MEMS sensors are introduced together with some current examples of commercialized products. Future challenges and trends will be discussed.
临床医学中有一些需要进行关键治疗决策的情况。这些情况需要准确性、快速性、可及性、成本效益和移动性。为了应对这些挑战，已经开发了新技术。微流控和微机电系统就是其中两项技术。微流控是一种涉及在蚀刻微通道中对微尺度流体进行处理的学科，它被用于构建实验室芯片系统来运行化学和生物分析。这些系统正在被转化为手持式设备，旨在用于远程环境或床边。MEMS 是集成在实验室芯片系统中的微机电元件或用作单个元件。基于 MEMS 的传感器是一个高度发达的领域，目前已有成功商业化的产品被整合到体外、离体和体内设备中。在本文中，介绍了几种微流控器件和 MEMS 传感器的实例，并介绍了一些当前商业化产品的实例。未来的挑战和趋势将被讨论。
