School of Life Science, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, PR China.
College of Science, Harbin Institute of Technology (Shenzhen), Shenzhen, China.
Biosens Bioelectron. 2019 Feb 1;126:697-706. doi: 10.1016/j.bios.2018.11.032. Epub 2018 Nov 20.
This article reviews the recent advances in microfluidic-chip integrated optical biosensors for simultaneous detection of multiple analytes. In particular, the principles and recent progress in different kinds of multiplex optical biosensors and their biological application were reviewed comprehensively. Sensors based on multiplexed detection have absolute advantages in analysis throughput than single assay. The microfluidic chip, a type of micro-total analysis system (µTAS), provides an ideal platform for integration of high-throughput biosensors. Compared with electronic biosensors, benefitted from the technical development in Micro-Electro-Mechanical System, there have been greater advances in the fabrication of optical sensors and microfluidic chip, and then promoting microfluidic-chip integrated optical biosensors for simultaneous detection of multiple analytes.
本文综述了用于同时检测多种分析物的微流控芯片集成光学生物传感器的最新进展。特别地，全面回顾了不同类型的多路复用光学生物传感器及其生物应用的原理和最新进展。与单分析相比，基于多路检测的传感器在分析通量方面具有绝对优势。微流控芯片作为一种微全分析系统（µTAS），为高通量生物传感器的集成提供了理想的平台。与电子生物传感器相比，得益于微机电系统技术的发展，在光学传感器和微流控芯片的制造方面取得了更大的进展，从而推动了用于同时检测多种分析物的微流控芯片集成光学生物传感器的发展。
