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微机电系统与肾脏病学：肾脏替代治疗技术的下一个前沿领域。

Microelectromechanical systems and nephrology: the next frontier in renal replacement technology.

机构信息

Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine and Division of Nephrology, Department of Medicine, School of Medicine, University of California, San Francisco, CA and Division of Nephrology, Department of Medicine, School of Medicine, University of California, San Francisco, CA.

出版信息

Adv Chronic Kidney Dis. 2013 Nov;20(6):516-35. doi: 10.1053/j.ackd.2013.08.006.

DOI:10.1053/j.ackd.2013.08.006
PMID:24206604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3866020/
Abstract

Microelectromechanical systems (MEMS) are playing a prominent role in the development of many new and innovative biomedical devices, but they remain a relatively underused technology in nephrology. The future landscape of clinical medicine and research will only see further expansion of MEMS-based technologies in device designs and applications. This enthusiasm stems from the ability to create small-scale device features with high precision in a cost-effective manner. MEMS also offers the possibility to integrate multiple components into a single device. The adoption of MEMS has the potential to revolutionize how nephrologists manage kidney disease by improving the delivery of renal replacement therapies and enhancing the monitoring of physiologic parameters. To introduce nephrologists to MEMS, this review will first define relevant terms and describe the basic processes used to fabricate devices. Next, a survey of MEMS devices being developed for various biomedical applications will be illustrated with current examples. Finally, MEMS technology specific to nephrology will be highlighted and future applications will be examined. The adoption of MEMS offers novel avenues to improve the care of kidney disease patients and assist nephrologists in clinical practice. This review will serve as an introduction for nephrologists to the exciting world of MEMS.

摘要

微机电系统（MEMS）在许多新的和创新的生物医学设备的发展中发挥着突出的作用，但它们在肾脏病学中仍然是一种相对未被充分利用的技术。在临床医学和研究的未来格局中，基于 MEMS 的技术在设备设计和应用中的进一步扩展将只会看到更多。这种热情源于以具有成本效益的方式创建具有高精度的小规模器件特征的能力。MEMS 还提供了将多个组件集成到单个设备中的可能性。MEMS 的采用有可能通过改善肾脏替代疗法的输送和增强生理参数的监测来彻底改变肾脏病医生对肾脏疾病的管理方式。为了向肾脏病医生介绍 MEMS，本综述将首先定义相关术语并描述用于制造器件的基本过程。接下来，将用当前的例子来说明正在为各种生物医学应用开发的 MEMS 器件。最后，将突出强调肾脏病学专用的 MEMS 技术，并研究未来的应用。MEMS 的采用为改善肾脏疾病患者的护理提供了新的途径，并为肾脏病医生在临床实践中提供了帮助。本综述将作为肾脏病医生进入令人兴奋的 MEMS 世界的入门指南。

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