Department of Internal Medicine.
Department of Medical Psychology and Psychotherapy.
Am J Transplant. 2010 Apr;10(4):821-827. doi: 10.1111/j.1600-6143.2010.03034.x. Epub 2010 Feb 25.
Between January 2000 and July 2009, 132 individuals inquired about altruistic kidney donation to strangers. These donors were willing to donate to genetically and emotionally unrelated patients. Some altruistic donors wished to donate to a specific person, but most wished to donate anonymously. In domino-paired donation, the altruistic donor donates to the recipient of an incompatible couple; the donor of that couple (domino-donor) donates to another couple or to the waiting list. In contrast to kidney-exchange donation where bilateral matching of couples is required, recipient and donor matching are unlinked in domino-paired donation. This facilitates matching for unsuccessful couples from the kidney-exchange program where blood type O prevails in recipients and is under-represented in donors. Fifty-one altruistic donors (39%) donated their kidney and 35 domino-donors were involved. There were 29 domino procedures, 24 with 1 altruistic donor and 1 domino-donor, 5 with more domino-donors. Eighty-six transplantations were performed. Donor and recipient blood type distribution in the couples limited allocation to blood type non-O waiting list patients. The success rate of domino-paired donation is dependent on the composition of the pool of incompatible pairs, but it offers opportunities for difficult to match pairs that were unsuccessful in the kidney-exchange program.
2000 年 1 月至 2009 年 7 月期间，共有 132 人咨询了向陌生人捐献无偿肾脏的事宜。这些捐献者愿意将肾脏捐献给与自己没有基因和情感联系的患者。一些无偿捐献者希望将肾脏捐献给特定的人，但大多数人希望匿名捐献。在多米诺配对捐献中，无偿捐献者将肾脏捐献给不匹配的夫妇中的受赠者；该对夫妇的捐献者（多米诺捐献者）将肾脏捐献给另一对夫妇或等待名单上的人。与需要双侧配对夫妇的肾脏交换捐献不同，在多米诺配对捐献中，受赠者和捐献者的配对是不相关的。这有利于在肾脏交换计划中为血型 O 在受赠者中占主导地位而在捐献者中代表性不足的不成功夫妇进行匹配。51 名无偿捐献者（39%）捐献了他们的肾脏，有 35 名多米诺捐献者参与其中。共有 29 例多米诺手术，其中 24 例有 1 名无偿捐献者和 1 名多米诺捐献者，5 例有更多的多米诺捐献者。共进行了 86 例移植手术。夫妇中供体和受者的血型分布限制了对非 O 血型等待名单患者的分配。多米诺配对捐献的成功率取决于不匹配夫妇群体的组成，但它为在肾脏交换计划中不成功的配对提供了机会。
