Division of Pediatric Emergency Medicine, BC Children's Hospital, Department of Pediatrics, University of British Columbia, Child & Family Research Institute, Vancouver, BC, Canada.
Fundam Clin Pharmacol. 2011 Feb;25(1):131-7. doi: 10.1111/j.1472-8206.2010.00816.x.
Increasing use of vitamins has been documented worldwide in children and adolescents, and potential for vitamin-drug interactions exists. The aim of this study was to identify vitamin use by children visiting a pediatric emergency department (ED). A survey of parents and/or patients 0-18 years was conducted at a large pediatric ED in Canada. A total of 1804 families were interviewed. The main outcome measure was prevalence of vitamin use by children in the preceding 3 months. A third (32.3%) of the patients in our cohort had used vitamins in the preceding 3 months, and 48% of them were taking vitamins daily. Over 8% of all children used vitamins within the last 24 h. The use of vitamins was higher with older patient and parental age (P<0.001), chronic patient illness (P<0.001), completed immunization (P<0.001), concurrent patient use of prescribed medications (P=0.02), higher parental education (P<0.01), and English as a primary language spoken at home (P=0.002). Prevalence of vitamin use among children in the ED is 32% in the preceding 3 months and 8% within the last 24 h. In light of these findings, pediatricians should ask about vitamin use and discuss with parents potential interactions and possible adverse effects.
在全球范围内,儿童和青少年使用维生素的情况越来越多,并且存在维生素与药物相互作用的可能性。本研究旨在确定在儿科急诊就诊的儿童使用维生素的情况。在加拿大的一家大型儿科急诊对 0-18 岁的父母和/或患者进行了一项调查。共采访了 1804 个家庭。主要观察指标为儿童在过去 3 个月内使用维生素的患病率。我们队列中的三分之一(32.3%)患者在过去 3 个月内使用过维生素,其中 48%的患者每天都服用维生素。超过 8%的儿童在过去 24 小时内使用过维生素。患者年龄较大和父母年龄较大(P<0.001)、慢性患者疾病(P<0.001)、完成免疫接种(P<0.001)、同时患者使用处方药物(P=0.02)、父母教育程度较高(P<0.01)以及在家中主要使用英语(P=0.002)时,使用维生素的情况更为常见。ED 中儿童在过去 3 个月内使用维生素的患病率为 32%,在过去 24 小时内使用维生素的患病率为 8%。鉴于这些发现,儿科医生应询问维生素的使用情况,并与家长讨论潜在的相互作用和可能的不良反应。