Taku Kyoko, Melby Melissa K, Takebayashi Jun, Mizuno Shoichi, Ishimi Yoshiko, Omori Toyonori, Watanabe Shaw
Information Center, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8636, Japan.
Asia Pac J Clin Nutr. 2010;19(1):33-42.
This study was conducted to clarify the effect of ingesting soy isoflavone extracts (not soy protein or foods containing isoflavones) on bone mineral density (BMD) in menopausal women. PubMed, CENTRAL, ICHUSHI, CNKI, Wanfang Data, CQVIP, and NSTL were searched for randomized controlled trials published in English, Japanese, or Chinese reporting the effects of soy isoflavone extracts on lumbar spine or hip BMD in menopausal women. Trials were identified and reviewed for inclusion and exclusion eligibility. Data on study design, participants, interventions, and outcomes were extracted. Eleven, seven, five, and five trials were finally selected for estimation of the effects on spine, femoral neck, hip total, and trochanter BMD, respectively. Meta-analysis including data from1240 menopausal women revealed that daily ingestion of an average of 82 (47-150) mg soy isoflavones (aglycone equivalent) for 6-12 months significantly increased spine BMD by 22.25 mg/cm2 (95% CI: 7.62, 32.89; p=0.002), or by 2.38% (95% CI: 0.93, 3.83; p=0.001) compared with controls (random-effects model). Subgroup analyses indicated that the varying effects of isoflavones on spine BMD across trials might be associated with study characteristics of intervention duration (6 vs. 12 months), region of participant (Asian vs. Western), and basal BMD (normal bone mass vs. osteopenia or osteoporosis). No significant effects on femoral neck, hip total, and trochanter BMD were found. Soy isoflavone extract supplements increased lumbar spine BMD in menopausal women. Further studies are needed to address factors affecting the magnitudes of effect on spine and to verify the effect on hip.
本研究旨在阐明摄入大豆异黄酮提取物（而非大豆蛋白或含异黄酮的食物）对绝经后女性骨密度（BMD）的影响。检索了PubMed、CENTRAL、Ichushi、中国知网、万方数据、维普资讯和国家科技图书文献中心，查找以英文、日文或中文发表的随机对照试验，这些试验报告了大豆异黄酮提取物对绝经后女性腰椎或髋部骨密度的影响。对试验进行识别并审查其纳入和排除资格。提取了关于研究设计、参与者、干预措施和结果的数据。最终分别选择了11项、7项、5项和5项试验来评估对脊柱、股骨颈、全髋和大转子骨密度的影响。对1240名绝经后女性的数据进行的荟萃分析显示，与对照组相比（随机效应模型），每天平均摄入82（47 - 150）毫克大豆异黄酮（苷元当量），持续6 - 12个月，可使脊柱骨密度显著增加22.25毫克/平方厘米（95%可信区间：7.62，32.89；p = 0.002），或增加2.38%（95%可信区间：0.93，3.83；p = 0.001）。亚组分析表明，不同试验中异黄酮对脊柱骨密度的不同影响可能与干预持续时间（6个月与12个月）、参与者地区（亚洲与西方）和基础骨密度（正常骨量与骨量减少或骨质疏松）等研究特征有关。未发现对股骨颈、全髋和大转子骨密度有显著影响。大豆异黄酮提取物补充剂可增加绝经后女性的腰椎骨密度。需要进一步研究以探讨影响脊柱效应大小的因素，并验证对髋部的影响。
