[3-β肾上腺素能阻滞剂对遗传性高血压大鼠血浆肾素活性的放射免疫测定作用]

[Action of 3-beta adrenolytics on plasma renin activity measured by radioimmunology in genetically hypertensive rats].

作者信息

Pape D, Lacroix P, Linée P, Le Pollés J B, Van den Driessche J

出版信息

C R Seances Soc Biol Fil. 1977;171(1):224-8.

PMID:20200

Abstract

Spontaneously hypertensive rats (SHR) have basal levels of plasma renin activity (PRA) lower than the ones observed in normal Sprague Dawley rats. Three beta blocking agents are orally administered to unanesthetized spontaneously hypertensive and normotensive rats. Propranolol and S 464 reduce PRA in spontaneously hypertensive and normotensive control rats. Pindolol do not lower PRA in normotensive rats but increases levels of PRA in spontaneously hypertensive rats. These results are discussed.

摘要

自发性高血压大鼠（SHR）的血浆肾素活性（PRA）基础水平低于正常斯普拉格-道利大鼠。对未麻醉的自发性高血压大鼠和正常血压大鼠口服三种β受体阻滞剂。普萘洛尔和S 464可降低自发性高血压大鼠和正常血压对照大鼠的PRA。吲哚洛尔不会降低正常血压大鼠的PRA，但会增加自发性高血压大鼠的PRA水平。对这些结果进行了讨论。

相似文献

1

[Action of 3-beta adrenolytics on plasma renin activity measured by radioimmunology in genetically hypertensive rats].

C R Seances Soc Biol Fil. 1977;171(1):224-8.

2

Antihypertensive effects of 12 beta adrenoceptor antagonists in conscious spontaneously hypertensive rats: relationship to changes in plasma renin activity, heart rate and sympathetic nerve function.

J Pharmacol Exp Ther. 1986 Jul;238(1):378-87.

3

The response of plasma catecholamines to the vasodepression caused by beta-adrenoceptor antagonists in the spontaneously hypertensive rat.

J Hypertens Suppl. 1986 Oct;4(3):S197-9.

4

[Effect of the beta-adrenergic blocking agent bupranolol on the plasma renin activity in normotensive rats].

Arzneimittelforschung. 1977;27(11):2063-6.

5

Plasma renin activity and angiotensin I and aldosterone concentrations in cats with hypertension associated with chronic renal disease.

Am J Vet Res. 1997 May;58(5):535-40.

6

Comparison of the effects on renin release of beta adrenergic antagonists with differing properties.

J Clin Invest. 1974 Dec;54(6):1413-9. doi: 10.1172/JCI107888.

7

[Action of 3 beta adrenolytics on plasma renin hyperactivity induced by isoprenaline in the anesthtized dog. Contribution to its mechanism of action].

C R Seances Soc Biol Fil. 1974;168(4-5):595-602.

8

Beta-adrenergic receptor blocking drugs, hypertension and plasma renin.

Br J Clin Pharmacol. 1975 Apr;2(2):159-64. doi: 10.1111/j.1365-2125.1975.tb01571.x.

9

Effects of beta adrenergic blocking agents on plasma renin activity in the conscious rabbit.

J Pharmacol Exp Ther. 1974 Jan;188(1):234-40.

10

Effects of prolonged administration of indenolol in hypertensive rats.

Arch Int Pharmacodyn Ther. 1983 Jul;264(1):82-95.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。