Pape D, Lacroix P, Linée P, Le Pollés J B, Van den Driessche J
C R Seances Soc Biol Fil. 1977;171(1):224-8.
Spontaneously hypertensive rats (SHR) have basal levels of plasma renin activity (PRA) lower than the ones observed in normal Sprague Dawley rats. Three beta blocking agents are orally administered to unanesthetized spontaneously hypertensive and normotensive rats. Propranolol and S 464 reduce PRA in spontaneously hypertensive and normotensive control rats. Pindolol do not lower PRA in normotensive rats but increases levels of PRA in spontaneously hypertensive rats. These results are discussed.
自发性高血压大鼠（SHR）的血浆肾素活性（PRA）基础水平低于正常斯普拉格-道利大鼠。对未麻醉的自发性高血压大鼠和正常血压大鼠口服三种β受体阻滞剂。普萘洛尔和S 464可降低自发性高血压大鼠和正常血压对照大鼠的PRA。吲哚洛尔不会降低正常血压大鼠的PRA，但会增加自发性高血压大鼠的PRA水平。对这些结果进行了讨论。
