β-肾上腺素能受体阻断药物、高血压与血浆肾素
Beta-adrenergic receptor blocking drugs, hypertension and plasma renin.
作者信息
Morgan T O, Roberts R, Carney S L, Louis W J, Doyle A E
出版信息
Br J Clin Pharmacol. 1975 Apr;2(2):159-64. doi: 10.1111/j.1365-2125.1975.tb01571.x.
Abstract
1 Propranolol and pindolol reduced both the blood pressure and plasma renin activity when given chronically to hypertensive patients. 2 There was no correlation between the fall in blood pressure and the fall in plasma renin activity. 3 Neither the basal nor the random plasma renin activity predicted the patients who would respond to beta-adrenergic receptor blocking drugs. 4 Oral propranolol reduced plasma renin activity but did not reduce blood pressure within 4 h of administration; oral pindolol reduced blood pressure but did not reduce plasma renin activity within 4 h of administration. 5 The reduction of blood pressure by propranolol and pindolol does not seem to be mediated by changes in plasma renin in most patients.
摘要
- 长期给予高血压患者普萘洛尔和吲哚洛尔后，血压和血浆肾素活性均降低。2. 血压下降与血浆肾素活性下降之间无相关性。3. 基础或随机血浆肾素活性均无法预测哪些患者会对β-肾上腺素能受体阻断药产生反应。4. 口服普萘洛尔可降低血浆肾素活性，但给药后4小时内未降低血压；口服吲哚洛尔可降低血压，但给药后4小时内未降低血浆肾素活性。5. 普萘洛尔和吲哚洛尔降低血压的作用在大多数患者中似乎并非由血浆肾素的变化介导。
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本文引用的文献
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Treatment of hypertension with propranolol.用普萘洛尔治疗高血压。
Br Med J. 1969 Jan 4;1(5635):7-16. doi: 10.1136/bmj.1.5635.7.
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Propranolol inhibition of renin secretion. A specific approach to diagnosis and treatment of renin-dependent hypertensive diseases.普萘洛尔对肾素分泌的抑制作用。一种诊断和治疗肾素依赖性高血压疾病的特定方法。
N Engl J Med. 1972 Dec 14;287(24):1209-14. doi: 10.1056/NEJM197212142872401.
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The use of prindolol (Visken) in the treatment of hypertension.心得宁（维斯肯）在高血压治疗中的应用。
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