T 细胞免疫球蛋白和粘蛋白结构域蛋白与免疫。
T cell Ig and mucin domain proteins and immunity.
机构信息
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
出版信息
J Immunol. 2010 Mar 15;184(6):2743-9. doi: 10.4049/jimmunol.0902937.
Abstract
Proteins of the transmembrane (or T cell) Ig and mucin domain (TIM) family are expressed by multiple cell types within the immune systems of rodents and humans. Studies over the last several years have suggested that these proteins may be promising targets for therapeutic manipulation of immune responses. This review discusses the progress that has been made in understanding TIM protein function in the immune system, as well as some of the unresolved issues that remain on the road to eventually targeting TIM proteins for enhancing or inhibiting immunity.
摘要
跨膜（或 T 细胞）免疫球蛋白和粘蛋白结构域（TIM）家族的蛋白质由啮齿动物和人类免疫系统中的多种细胞类型表达。过去几年的研究表明，这些蛋白质可能是免疫反应治疗干预的有前途的靶点。本综述讨论了在理解 TIM 蛋白在免疫系统中的功能方面所取得的进展，以及在最终针对 TIM 蛋白以增强或抑制免疫的道路上仍存在的一些未解决的问题。
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Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells.负性免疫调节因子Tim-3在丙型肝炎病毒感染的T细胞上过度表达，阻断该因子可挽救功能失调的CD4+和CD8+ T细胞。
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