肾损伤分子 1（KIM-1）：一种多功能糖蛋白和生物标志物（综述）。
Kidney Injury Molecule 1 (KIM-1): a Multifunctional Glycoprotein and Biological Marker (Review).
机构信息
Leading Researcher, Department of Predicting the Effectiveness of Conservative Therapy; P. Hertsen Moscow Oncology Research Institute - Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 3, 2 Botkinsky Proezd, Moscow, 125284, Russia.
Professor, Head of the Department of Predicting the Effectiveness of Conservative Therapy; P. Hertsen Moscow Oncology Research Institute - Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 3, 2 Botkinsky Proezd, Moscow, 125284, Russia; Professor, Department of Biology; Pirogov Russian National Research Medical University, 1 Ostrovitianova St., Moscow, 117997, Russia.
出版信息
Sovrem Tekhnologii Med. 2021;13(3):64-78. doi: 10.17691/stm2021.13.3.08. Epub 2021 Jun 28.
KIM-1 (kidney injury molecule 1) is a transmembrane glycoprotein also known as HAVcr-1 and TIM-1 belongs to the T-cell immunoglobulin and mucin domain family (TIM) of proteins. TIM glycoproteins are presented on the immune cells and participate in the regulation of immune reactions. KIM-1 differs from other members of its family in that it is expressed not only by immunocompetent cells but epithelial cells as well. Cellular and humoral effects mediated by KIM-1 are involved in a variety of physiological and pathophysiological processes. Current understanding of the mechanisms determining the participation of KIM-1 in viral invasion, the immune response regulation, adaptive reactions of the kidney epithelium to acute ischemic or toxic injury, in progression of chronic renal diseases, and kidney cancer development have been presented in this review. Data of clinical researches demonstrating the association of KIM-1 with viral diseases and immune disorders have also been analyzed. Potential application of KIM-1 as urinary or serological marker in renal and cardiovascular diseases has been considered.
肾损伤分子 1（KIM-1）是一种跨膜糖蛋白，也被称为 HAVcr-1 和 TIM-1，属于 T 细胞免疫球蛋白和粘蛋白结构域家族（TIM）的蛋白。TIM 糖蛋白存在于免疫细胞上，并参与免疫反应的调节。KIM-1 与其家族的其他成员不同，它不仅由免疫活性细胞表达，而且还由上皮细胞表达。KIM-1 介导的细胞和体液作用参与了多种生理和病理生理过程。本综述介绍了确定 KIM-1 参与病毒入侵、免疫反应调节、肾上皮对急性缺血或毒性损伤的适应性反应、慢性肾脏病进展以及肾癌发展的机制的最新认识。还分析了临床研究中与 KIM-1 与病毒疾病和免疫紊乱相关的数据。考虑了将 KIM-1 作为尿液或血清标志物在肾脏和心血管疾病中的潜在应用。
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